1. Anti-infection
    Autophagy
  2. Parasite
    Influenza Virus
    Autophagy
  3. Nitazoxanide

Nitazoxanide (Synonyms: NTZ; NSC 697855)

Cat. No.: HY-B0217 Purity: 99.95%
Handling Instructions

Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model.

For research use only. We do not sell to patients.

Nitazoxanide Chemical Structure

Nitazoxanide Chemical Structure

CAS No. : 55981-09-4

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Nitazoxanide:

Top Publications Citing Use of Products

    Nitazoxanide purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Oct 9;9(10):1032.

    Western blot showing the cell cycle and autophagy-related proteins after 48 h of treatment with 200 μM Nitazoxanide (NTZ) and/or 500 nM Torin 1 or 30 mM Chloroquine (CQ).

    Nitazoxanide purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Oct 9;9(10):1032.

    Western blot showing SQSTM1 and LC3 levels in LN229 cells after treatment with 200 μM Nitazoxanide (NTZ) and 200 nM Bafilomycin A1 (BAF) for 48 h.
    • Biological Activity

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    • Customer Review

    Description

    Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM[1]. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model[2].

    In Vitro

    Giardia lamblia, a flagellated protozoan, is the most common causative agent of persistent diarrhea worldwide[1].
    Nitazoxanide exhibits effect on G. lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: Human cancer colon Caco2 cells were incubated with increasing numbers of Giardia lamblia trophozoites (103 to 106 parasites per well)
    Concentration: 30 μM
    Incubation Time: 24 hours
    Result: 70 to 90% of the trophozoites remained attached to the Caco2 cells for a period of 24 to 48 h in the absence of Nitazoxanide and at an initial inoculum density of 105 parasites per well.
    The number of parasites still attached to Caco2 cells after 24 h decreased to less than 20% of the control value in the presence of 30 μM Nitazoxanide with an inoculum density of 105 trophozoites.
    In Vivo

    Nitazoxanide exhibits a wide spectrum of in vivo activity against a broad spectrum of intestinal parasites, such as Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis, the apicomplexan Cryptosporidium parvum, and enteric bacteria infecting animals and humans[1].
    Nitazoxanide (50, 75 or 100 mg/kg/day; administered daily by intragastric for up to 25 days) reduces the mortality of Japanese encephalitis virus (JEV) strain-infected mice and protected mice from a lethal dose challenge of JEV[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Three-week old female Chinese Kunming mice (12–14 g body weight) were infected intraperitoneally with JEV[2]
    Dosage: 50, 75 or 100 mg/kg/day
    Administration: Administered intragastrically by gavage
    Result: 50 mg/kg/day, 75 mg/kg/day and 100 mg/kg/day led to 30%, 70% and 90% mice survival, respectively.
    Molecular Weight

    307.28

    Formula

    C12H9N3O5S

    CAS No.
    SMILES

    O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2OC(C)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (325.44 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2544 mL 16.2718 mL 32.5436 mL
    5 mM 0.6509 mL 3.2544 mL 6.5087 mL
    10 mM 0.3254 mL 1.6272 mL 3.2544 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3.25 mg/mL (10.58 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.95%

    References
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