1. Anti-infection
    Autophagy
  2. Influenza Virus
    Autophagy
  3. Nitazoxanide

Nitazoxanide (Synonyms: NTZ; NSC 697855)

Cat. No.: HY-B0217 Purity: 95.24%
Handling Instructions

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent.

For research use only. We do not sell to patients.

Nitazoxanide Chemical Structure

Nitazoxanide Chemical Structure

CAS No. : 55981-09-4

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 288 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Nitazoxanide:

Top Publications Citing Use of Products

Publications Citing Use of MCE Nitazoxanide

    Nitazoxanide purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Oct 9;9(10):1032.

    Western blot showing the cell cycle and autophagy-related proteins after 48 h of treatment with 200 μM Nitazoxanide (NTZ) and/or 500 nM Torin 1 or 30 mM Chloroquine (CQ).

    Nitazoxanide purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Oct 9;9(10):1032.

    Western blot showing SQSTM1 and LC3 levels in LN229 cells after treatment with 200 μM Nitazoxanide (NTZ) and 200 nM Bafilomycin A1 (BAF) for 48 h.
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    Description

    Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Target: Others Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. In vitro studies demonstrated much broader activity. Dr. Rossignol co-founded Romark Laboratories, with the goal of bringing nitazoxanide to market as an anti-parasitic drug. Initial studies in the USA were conducted in collaboration with Unimed Pharmaceuticals, Inc. (Marietta, GA) and focused on development of the drug for treatment of cryptosporidiosis in AIDS. The anti-protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. It has also been shown to have activity against influenza A virus in vitro. The mechanism appears to be by selectively blocking the maturation of the viral hemagglutinin at a stage preceding resistance to endoglycosidase H digestion. This impairs hemagglutinin intracellular trafficking and insertion of the protein into the host plasma membrane.

    Clinical Trial
    Molecular Weight

    307.28

    Formula

    C₁₂H₉N₃O₅S

    CAS No.

    55981-09-4

    SMILES

    O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2OC(C)=O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (325.44 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2544 mL 16.2718 mL 32.5436 mL
    5 mM 0.6509 mL 3.2544 mL 6.5087 mL
    10 mM 0.3254 mL 1.6272 mL 3.2544 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3.25 mg/mL (10.58 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Cat. No.:
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