55981-09-4
Chemical Structure
Nitazoxanide
Synonym(s): NTZ; NSC 697855
- No. CAS: 55981-09-4
- Formula:C12H9N3O5S
- Molecular Weight:307.28
IUPAC Name: 2-((5-nitrothiazol-2-yl)carbamoyl)phenyl acetate
InChIKey: YQNQNVDNTFHQSW-UHFFFAOYSA-N
SMILES: O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2OC(C)=O
Biological Activity: Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM[1]. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model[2].
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Nitazoxanide | 99.28% | Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model. | ||||||||||||||||||||
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Nitazoxanide (Standard) | 98.69% | Nitazoxanide (Standard) is the analytical standard of Nitazoxanide. This product is intended for research and analytical applications. Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model. | ||||||||||||||||||||
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Nitazoxanide-d4 | Nitazoxanide-d4 is the deuterium labeled Nitazoxanide, which is an antiprotozoal agent. | |||||||||||||||||||||
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References
- [1]. Rossignol JF, et al. Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level. J Biol Chem. 2009 Oct 23;284(43):29798-808. [Content Brief]
- [2]. Zixue Shi, et al. Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model. Virol J. 2014 Jan 23;11:10. [Content Brief]
