1. NF-κB
    MAPK/ERK Pathway
    Metabolic Enzyme/Protease
  2. NF-κB
    p38 MAPK
    MMP
  3. SM-7368

SM-7368 

Cat. No.: HY-116626
Handling Instructions

SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis .

For research use only. We do not sell to patients.

SM-7368 Chemical Structure

SM-7368 Chemical Structure

CAS No. : 380623-76-7

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Description

SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis [2].

IC50 & Target[1][2]

NF-κB

 

MMP-9

 

p38 MAP kinase

 

In Vitro

SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines[1].
SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line[2].
SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: HT1080 human fibrosarcoma cells
Concentration: 0, 1, 5, 10, 15, 20, and 25 μM
Incubation Time: 24 hours
Result: Greatly inhibited TNF-α (20 ng/mL)-induced MMP-9 upregulation in a concentration-dependent manner.
Molecular Weight

328.69

Formula

C₁₀H₅ClN₄O₅S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SM-7368
Cat. No.:
HY-116626
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