380623-76-7
380623-76-7
Chemical Structure
SM-7368
- CAS No.: 380623-76-7
- Formula:C10H5ClN4O5S
- Molecular Weight:328.69
IUPAC Name: 3-chloro-4-nitro-N-(5-nitrothiazol-2-yl)benzamide
InChIKey: XCHLNGBTHLJLFG-UHFFFAOYSA-N
SMILES: ClC1=C(C=CC(C(NC2=NC=C(S2)[N+]([O-])=O)=O)=C1)[N+]([O-])=O
Biological Activity: SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis [2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SM-7368 | 99.77% | SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis . | ||||||||||||||||||||
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References
- [1]. Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol Nutr Food Res. 2010 Oct;54(10):1458-67. [Content Brief]
- [2]. Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005 Oct 21;336(2):716-22. [Content Brief]
