2. JAK/STAT Signaling Stem Cell/Wnt Immunology/Inflammation Apoptosis
  3. STAT Interleukin Related Apoptosis
  4. NTZ-24

NTZ-24 is a selective STAT3 pathway inhibitor. NTZ-24 suppresses STAT3 phosphorylation at Tyr705, blocks STAT3-DNA interaction, and downregulates the levels of STAT3 downstream target proteins. NTZ-24 induces cell-cycle arrest and promotes apoptosis in cancer cells. NTZ-24 exerts significant antiproliferative activity against HeLa cells (IC50 = 3.3 μM). NTZ-24 can be used for the research of cervical cancer.

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NTZ-24

NTZ-24 Chemical Structure

CAS No. : 69819-42-7

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NTZ-24 Related Antibodies

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STAT3 STAT5 STAT6 STAT1

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

NTZ-24 is a selective STAT3 pathway inhibitor. NTZ-24 suppresses STAT3 phosphorylation at Tyr705, blocks STAT3-DNA interaction, and downregulates the levels of STAT3 downstream target proteins. NTZ-24 induces cell-cycle arrest and promotes apoptosis in cancer cells. NTZ-24 exerts significant antiproliferative activity against HeLa cells (IC50 = 3.3 μM). NTZ-24 can be used for the research of cervical cancer[1].

IC50 & Target[1]

STAT3

0.8 μM (IC50)

IL-6

 

In Vitro

NTZ-24 (compound 24) inhibits the IL-6/JAK/STAT3 pathway in HEK-Blue IL-6 cells with an IC50 of 0.8 μM[1].
NTZ-24 (48 h) inhibits the proliferation of HeLa epithelial carcinoma cells with an IC50 of 3.3 μM[1].
NTZ-24 (10-50 μM; 48 h) exhibits low cytotoxicity in human normal embryonic kidney HEK 293T cells, with 8.0% and 19.1% cell viability inhibition at 10 μM and 50 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NTZ-24 Related Antibodies
Molecular Weight

318.14

Formula

C10H5Cl2N3O3S
CAS No.
SMILES

O=C(C1=CC=C(C(Cl)=C1)Cl)NC2=NC=C([N+]([O-])=O)S2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NTZ-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NTZ-2469819-42-7NTZ24NTZ 24STATInterleukin RelatedApoptosisILapoptosisHEK-Blue IL-6 cellsHeLa epithelial carcinoma cellsIL-6/JAK/STAT3 pathwaycervical cancerhuman normal embryonic kidney HEK 293T cellsG0/G1-phase cell-cycle arrestSTAT5STAT3Inhibitorinhibitorinhibit

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