1. Anti-infection
    Autophagy
  2. Bacterial
    Autophagy
  3. Tizoxanide

Tizoxanide (Synonyms: TIZ)

Cat. No.: HY-12687 Purity: 99.76%
Handling Instructions

Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses.

For research use only. We do not sell to patients.

Tizoxanide Chemical Structure

Tizoxanide Chemical Structure

CAS No. : 173903-47-4

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 312 In-stock
Estimated Time of Arrival: December 31
100 mg USD 552 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. IC50 value: Target: Antiviral agent in vitro: Tizoxanide inhibited virus replication of all CIVs with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively [2]. Nitazoxanide and its primary metabolite, tizoxanide, inhibit hepatitis C virus (HCV) replication in HCV replicon systems. Interestingly, serial passage in nitazoxanide or tizoxanide resulted in increased sensitivity to alpha interferon 2b: EC(50)s and EC(90)s were reduced three- and eightfold, respectively [3].

Molecular Weight

265.25

Formula

C₁₀H₇N₃O₄S

CAS No.

173903-47-4

SMILES

O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 38 mg/mL (143.26 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7700 mL 18.8501 mL 37.7003 mL
5 mM 0.7540 mL 3.7700 mL 7.5401 mL
10 mM 0.3770 mL 1.8850 mL 3.7700 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Tizoxanide
Cat. No.:
HY-12687
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