1. Immunology/Inflammation
  2. IRAK
  3. IRAK4-IN-6

IRAK4-IN-6 

Cat. No.: HY-130253 Purity: 99.92%
Handling Instructions

IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma.

For research use only. We do not sell to patients.

IRAK4-IN-6 Chemical Structure

IRAK4-IN-6 Chemical Structure

CAS No. : 2454244-02-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 555 In-stock
Estimated Time of Arrival: December 31
Powder + Solvent
10 mM * 1 mL
ready for reconstitution
USD 555 In-stock
Estimated Time of Arrival: December 31
Powder
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma[1].

IC50 & Target

IC50: 4 nM (IRAK4)[1]

Molecular Weight

504.59

Formula

C₂₅H₃₂N₁₀O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (247.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9818 mL 9.9090 mL 19.8181 mL
5 mM 0.3964 mL 1.9818 mL 3.9636 mL
10 mM 0.1982 mL 0.9909 mL 1.9818 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
IRAK4-IN-6
Cat. No.:
HY-130253
Quantity:
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