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Cat. No.: HY-10512R

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AR-A014418 (Standard)

(Synonyms: AR 0133418 (Standard); GSK 3β inhibitor VIII (Standard); AR 014418 (Standard))

AR-A014418 (Standard) is the analytical standard of AR-A014418. This product is intended for research and analytical applications. AR-A014418 is a potent, selective and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM).

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 487021-52-3
Formula: C₁₂H₁₂N₄O₄S
Molecular Weight:308.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AR-A014418 (Standard) Chemical Structure

CAS No.: 487021-52-3

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Chemical Information
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Bioz

Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 487021-52-3
Molecular Weight 308.31
Formula C₁₂H₁₂N₄O₄S
SMILES

O=C(NCC1=CC=C(OC)C=C1)NC2=NC=C([N+]([O-])=O)S2
Synonyms

AR 0133418 (Standard); GSK 3β inhibitor VIII (Standard); AR 014418 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Bhat R, Xue Y, Berg S, Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem. 2003 Nov 14;278(46):45937-45. [Content Brief]

[2]. Carter YM, et al. Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth. Cancer Biol Ther. 2014 May;15(5):510-5. [Content Brief]

[3]. Koh SH, et al. Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS. Exp Neurol. 2007 Jun;205(2):336-46 [Content Brief]

[4]. Martins DF, et al. The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice. J Pain. 2011 Mar;12(3):315-22. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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