1. Anti-infection
  2. HSV
  3. Ganciclovir

Ganciclovir (Synonyms: BW 759; 2'-Nor-2'-deoxyguanosine)

Cat. No.: HY-13637 Purity: 99.77%
Handling Instructions

Ganciclovir is a potent herpes simplex virus (HSV)inhibitor, including cytomegalovirus (CMV), with an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).

For research use only. We do not sell to patients.

Ganciclovir Chemical Structure

Ganciclovir Chemical Structure

CAS No. : 82410-32-0

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10 mM * 1  mL in DMSO USD 73 In-stock
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5 g USD 139 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Ganciclovir purchased from MCE. Usage Cited in: Eur J Pharm Sci. 2019 Jan 15;127:29-37.

    Viral reporter GFP expression after inoculation and compound treatment. Infected cells treated with DMSO control, BIO, Ganciclovir (GCV) or Letermovir (LTR)
    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review


    Ganciclovir is a potent herpes simplex virus (HSV)inhibitor, including cytomegalovirus (CMV), with an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).

    IC50 & Target

    IC50: 5.2 μM (FHV-1)[1]

    In Vitro

    Ganciclovir is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir[2].The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase.Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase[3].

    In Vivo

    In adult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion is observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice[4].

    Clinical Trial
    Molecular Weight




    CAS No.





    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 60 mg/mL (235.08 mM; Need ultrasonic)

    H2O : 3.67 mg/mL (14.38 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9180 mL 19.5902 mL 39.1803 mL
    5 mM 0.7836 mL 3.9180 mL 7.8361 mL
    10 mM 0.3918 mL 1.9590 mL 3.9180 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3 mg/mL (11.75 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 3 mg/mL (11.75 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 3 mg/mL (11.75 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    Animal Administration

    Rats: Two albino rats non-immunized for MCMV are used in the study. After being weighed, two adult rats undergo peritoneal injections. The first rat receives 50 mg/kg of ganciclovir twice a day (i.e. 100 mg/kg/day), for a total of 3 days or 6 injections. The second rat is used as a negative control and received intraperitoneal injections of glucose solution. After the 6th injection, the two rats are sacrified; blood and perilymphatic fluids are collected for analysis[4].

    Mice: Non-inbred Oncins France 1 (OF1) mice are used in the study. Ganciclovir is diluted in 5% glucose serum to a concentration of 5 mg/mL and administered intraperitoneally in newborn mice at a dose of 50 mg/kg twice a day. Five injections are administered in total[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.


    Purity: 99.77%

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    GanciclovirBW 7592'-Nor-2'-deoxyguanosineBW759BW-759HSVAntibioticHerpes simplex virusInhibitorinhibitorinhibit

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