1. Anti-infection
    Cell Cycle/DNA Damage
  2. CMV
    HSV
    Antibiotic
    Nucleoside Antimetabolite/Analog
  3. Ganciclovir

Ganciclovir (Synonyms: BW 759; 2'-Nor-2'-deoxyguanosine)

Cat. No.: HY-13637 Purity: 99.77%
Handling Instructions

Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).

For research use only. We do not sell to patients.

Ganciclovir Chemical Structure

Ganciclovir Chemical Structure

CAS No. : 82410-32-0

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Ganciclovir:

Top Publications Citing Use of Products

    Ganciclovir purchased from MCE. Usage Cited in: Eur J Pharm Sci. 2019 Jan 15;127:29-37.

    Viral reporter GFP expression after inoculation and compound treatment. Infected cells treated with DMSO control, BIO, Ganciclovir (GCV) or Letermovir (LTR)
    • Biological Activity

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    • Customer Review

    Description

    Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3].

    IC50 & Target[1][2][3]

    CMV

     

    HSV-1

     

    HSV-2

     

    FHV-1

    5.2 μM (IC50)

    In Vitro

    Ganciclovir (BW 759) is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir[4].The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase[5].

    In Vivo

    Ganciclovir (BW 759) (1-80 mg/kg; i.h.; daily for 5 days) delays murine cytomegalovirus (MCMV)-induced wasting syndrome and mortality[6].

    Animal Model: Severe combined immunodeficiency (SCID) mice (MCMV infection)[6]
    Dosage: 1-80 mg/kg
    Administration: I.h.; daily for 5 days
    Result: Dose dependently delayed MCMV-induced wasting syndrome and mortality.
    Clinical Trial
    Molecular Weight

    255.23

    Formula

    C₉H₁₃N₅O₄

    CAS No.

    82410-32-0

    SMILES

    O=C1NC(N)=NC2=C1N=CN2COC(CO)CO

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 60 mg/mL (235.08 mM; Need ultrasonic)

    H2O : 3.67 mg/mL (14.38 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9180 mL 19.5902 mL 39.1803 mL
    5 mM 0.7836 mL 3.9180 mL 7.8361 mL
    10 mM 0.3918 mL 1.9590 mL 3.9180 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3 mg/mL (11.75 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 3 mg/mL (11.75 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 3 mg/mL (11.75 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.77%

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    Keywords:

    GanciclovirBW 7592'-Nor-2'-deoxyguanosineBW759BW-759CMVHSVAntibioticNucleoside Antimetabolite/AnalogCytomegalovirusHerpes simplex virusDNAviruseherpesgroupinfectionserotypepolymerasereplicationInhibitorinhibitorinhibit

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