Identification of novel nucleotide phosphonate analogs with potent anti-HCMV activity

  • Bioorg Med Chem Lett. 1998 Dec 15;8(24):3561-6. doi: 10.1016/s0960-894x(98)00649-0.
P Nguyen-Ba  1 ,  N Turcotte ,  L Yuen ,  J Bédard ,  M Quimpère ,  L Chan
Affiliations
  • 1. BioChem Therapeutic Inc., Laval, Québec, Canada.
PMID: 9934471 DOI: 10.1016/s0960-894x(98)00649-0
Abstract

We have recently described the discovery of new leads in the area of anti-HCMV research. Further structure-activity relationship studies have allowed us to identify potent and selective anti-HCMV nucleotide analogs. The synthesis as well as structure-activity relationship studies are described.