1. Others Anti-infection Cell Cycle/DNA Damage
  2. Isotope-Labeled Compounds CMV HSV Antibiotic Nucleoside Antimetabolite/Analog
  3. Ganciclovir-d5

Ganciclovir-d5  (Synonyms: BW 759-d5; 2'-Nor-2'-deoxyguanosine-d5)

Cat. No.: HY-13637S
COA Handling Instructions

Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3].

For research use only. We do not sell to patients.

Ganciclovir-d<sub>5</sub> Chemical Structure

Ganciclovir-d5 Chemical Structure

CAS No. : 1189966-73-1

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Based on 1 publication(s) in Google Scholar

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Description

Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.26

Formula

C9H8D5N5O4

CAS No.
Unlabeled CAS

82410-32-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(NC2=C1N=CN2COC([2H])(C([2H])(O)[2H])C([2H])(O)[2H])N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 94.38%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ganciclovir-d5
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