82410-32-0
Chemical Structure
Ganciclovir
Synonym(s): BW 759; 2'-Nor-2'-deoxyguanosine
- CAS 番号: 82410-32-0
- Formula:C9H13N5O4
- Molecular Weight:255.23
IUPAC Name: 2-amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1,9-dihydro-6H-purin-6-one
InChIKey: IRSCQMHQWWYFCW-UHFFFAOYSA-N
SMILES: O=C1NC(N)=NC2=C1N=CN2COC(CO)CO
Biological Activity: Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].
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Ganciclovir | 99.89% | Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain. | ||||||||||||||||||||
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Ganciclovir (Standard) | 99.77% | Ganciclovir (Standard) is the analytical standard of Ganciclovir. This product is intended for research and analytical applications. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain. | ||||||||||||||||||||
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Ganciclovir-d5 | 98.32% | Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1). | ||||||||||||||||||||
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Similarity Score 0.87
HY-13637BGanciclovir hydrate -
Similarity Score 0.83
HY-17422Acyclovir -
Similarity Score 0.80
HY-1371819-Carboxymethoxymethylguanine -
Similarity Score 0.78
HY-17424Penciclovir -
Similarity Score 0.77
HY-162069Antiviral agent 47 -
Similarity Score 0.76
HY-116174Omaciclovir -
Similarity Score 0.76
HY-41344RGanciclovir mono-O-acetate (Standard) -
Similarity Score 0.75
HY-17422S1Acyclovir-d4 -
Similarity Score 0.75
HY-17422AAcyclovir sodium -
Explore the MedChemAI to find more analogs
References
- [1]. Faulds D, et al. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs. 1990;39(4):597-638. [Content Brief]
- [2]. Maggs DJ, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403. [Content Brief]
- [3]. Boujemla I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016;132:111-115. [Content Brief]
