Acyclovir sodium (Synonyms: Aciclovir sodium; Acycloguanosine sodium)

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Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC₅₀ values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia.

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Acyclovir sodium Chemical Structure

CAS No. : 69657-51-8

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Other In-stock Forms of Acyclovir sodium:

Other Forms of Acyclovir sodium:

Acyclovir In-stock
Acyclovir alaninate Get quote

7 Publications Citing Use of MCE Acyclovir sodium

•Microchem J. 2021, 106587.

: Acyclovir sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Mar 27;162:114595. [Abstract]; Acyclovir (ACV; 2.5 μM; 48 h) significantly inhibits the expression of gD in HSV-2-infected HeLa, Vero, Beas-2B and HaCaT cells.

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Description

IC₅₀ & Target^[2]

HSV-1

0.85 μM (IC₅₀)

HSV-2

0.86 μM (IC₅₀)

In Vitro

Acyclovir (Aciclovir) sodium (3-100 µM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent^[1].
Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner^[1].
Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Jurkat, U937 and K562 leukemia cells
Concentration:	3, 10, 30 and 100 µM
Incubation Time:	24, 48 and 72 hours
Result:	Showed a dose- and time-dependent reduction of cell viability.

Apoptosis Analysis^[1]

Cell Line:	Jurkat cells
Concentration:	10 and 100 µM
Incubation Time:	24, 48 and 72 hours
Result:	Increased of caspase-3 activity and cleavaged the internucleosomal DNA.

Cell Cycle Analysis^[1]

Cell Line:	Jurkat cells
Concentration:	10 and 100 µM
Incubation Time:	24, 48 and 72 hours
Result:	Revealed a dose-dependent accumulation of cells in S phase after 24 and 48 h. Showed a dose-dependent increase of the sub-G1 hypodiploid peak after 72 h.

In Vivo

Acyclovir (Aciclovir) sodium (20 mg/kg; p.o.; three times daily; for 10 d; BALB/c mice) suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production^[3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1^[3]
Dosage:	20 mg/kg
Administration:	Oral administration; three times daily; for 10 days
Result:	Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.

Clinical Trial

Molecular Weight

248.19

Formula

C₈H₁₁N₅NaO₃

CAS No.

69657-51-8

SMILES

O=C1N=C(N)NC2=C1N=CN2COCCO.[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Benedetti S, et, al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15;215:80-85. [Content Brief]

[2]. Suzuki M, et, al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61. [Content Brief]

[3]. Li Z, et, al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10(5):251-7. [Content Brief]

[4]. Lönnqvist B, et, al. Oral acyclovir as prophylaxis for bacterial infections during induction therapy for acute leukaemia in adults. The Leukemia Group of Middle Sweden. Support Care Cancer. 1993 May;1(3):139-44. [Content Brief]

Acyclovir sodium Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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