2. Anti-infection Cell Cycle/DNA Damage
  3. CMV HSV Antibiotic Nucleoside Antimetabolite/Analog
  4. Ganciclovir hydrate

Ganciclovir hydrate  (Synonyms: BW-759 hydrate; 2'-Nor-2'-deoxyguanosine hydrate)

Cat. No.: HY-13637B
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Ganciclovir (BW 759) hydrate, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir hydrate also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir hydrate inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir hydrate has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.

For research use only. We do not sell to patients.

CAS No. : 1359968-33-4

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Ganciclovir hydrate Related Antibodies

Top Publications Citing Use of Products
Bio/Physico-chemical Assay
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Microbiological Assay
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IF

    Ganciclovir hydrate purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2023 Nov 27;15(12):2680.

    GCV (1-30 μM) exhibited a dose-dependent decrease in newly synthesized DNA due to its inhibitory impact on the viral polymerase processing activity.

    Ganciclovir hydrate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2022 Jul 20;20(1):340.  [Abstract]

    Long-term GCV (50 mg/kg, ip)-trigged nanoparticle-based therapy in ovarian cancer model.

    Ganciclovir hydrate purchased from MedChemExpress. Usage Cited in: Sci Data. 2022 Oct 8;9(1):610.  [Abstract]

    Exemplary overviews of one screening plate for each virus screen. Individual images of each well were stitched yielding the overviews. First two columns of each plate contained DMSO control solvent, the following 20 columns PCL compounds, and the last two columns the positive controls (BafA1 for RV and IAV, and GCV (25 μM) for HSV-1). Scale bar represents 10 mm.

    Ganciclovir hydrate purchased from MedChemExpress. Usage Cited in: Cell. 2020 Nov 25;183(5):1402-1419.e18.  [Abstract]

    In vivo studies of miR-124-HSV-tk-GFP teratomas in the presence of GCV administration (80mg/kg/d, 10 weeks) using both intratumoral (IT) and intratumoral and intraperitoneal injection methods. A heatmap showing cell type fraction log fold-change for each teratoma replicate compared to a control miR-124-HSV-tk-GFP teratoma in the absence of GCV. Z-scores for each cell type fraction change are plotted as well, with standard deviations calculated using a pooled variance.

    Ganciclovir hydrate purchased from MedChemExpress. Usage Cited in: Cells. 2019 Dec 20;9(1):31.  [Abstract]

    Antiviral effects of eltrombopag in combination with Ganciclovir (0.61-10000 nM). Effects of equimolar drug concentrations on HCMV LA expression in HCMV Hi91 (MOI 0.02) HFFs 120 h post infection. * p < 0.05 compared to either single treatment.

    Ganciclovir hydrate purchased from MedChemExpress. Usage Cited in: Eur J Pharm Sci. 2019 Jan 15:127:29-37.  [Abstract]

    Viral reporter GFP expression after inoculation and compound treatment. Infected cells treated with DMSO control, BIO, Ganciclovir (GCV) or Letermovir (LTR)

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    Description

    Ganciclovir (BW 759) hydrate, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir hydrate also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir hydrate inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir hydrate has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].

    IC50 & Target[1][2][3]

    CMV

     

    HSV-1

     

    HSV-2

     

    FHV-1

    5.2 μM (IC50)

    In Vitro

    Ganciclovir (BW 759) is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median Ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 μM versus 72 μM for acyclovir[4].
    The primary mechanism of Ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ganciclovir hydrate Related Antibodies
    In Vivo

    Ganciclovir (BW 759) (50 mg/kg; i.p.; twice a day for five injections) significantly decreases white blood cells, red blood cells and platelets in newborn mice, and can diffuse into the brain and the perilymphatic space of the inner ear[3].
    Ganciclovir (1-80 mg/kg; i.h.; daily for 5 days) delays murine cytomegalovirus (MCMV)-induced wasting syndrome and mortality[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Non-inbred Oncins France 1 (OF1) mice and albino rats non-immunized for MCMV[3]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection, twice a day for five injections (mice) or 3 days (adult rats) (Pharmacokinetic Study)
    Result: In adult rats, the intracochlear diffusion of Ganciclovir was shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion was observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of Ganciclovir showed a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but became undetectable by 2 h after injection.
    Significantly decreased white blood cells, red blood cells and platelets in newborn mice.
    Animal Model: Female SCID mice inoculated with MCMV[6]
    Dosage: 0, 1, 10, 80 and 160 mg/kg
    Administration: Subcutaneous injection, once daily for 5 days
    Result: Dose dependently delayed the wasting syndrome and mortality in a dose range up to 80 mg/kg per day, whereas a dose of 160 mg/kg per day induced reversible side-effects.
    Molecular Weight

    273.25

    Formula

    C9H15N5O5
    CAS No.
    SMILES

    O=C1N=C(NC2=C1N=CN2COC(CO)CO)N.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
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    Ganciclovir hydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ganciclovir1359968-33-4BW-7592'-Nor-2'-deoxyguanosineBW759BW 759CMVHSVAntibioticNucleoside Antimetabolite/AnalogCytomegalovirusHerpes simplex virusDNAviruseherpesgroupinfectionserotypepolymerasereplicationCNS penetrationorally activecytomegalovirusInhibitorinhibitorinhibit

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