Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication

  • Bioorg Med Chem Lett. 2001 Aug 6;11(15):1993-5. doi: 10.1016/s0960-894x(01)00352-3.
M J Slater  1 ,  R Baxter ,  R W Bonser ,  S Cockerill ,  K Gohil ,  N Parry ,  E Robinson ,  R Randall ,  C Yeates ,  W Snowden ,  A Walters
Affiliations
  • 1. GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, SG1 2NY, Stevenage, UK. [email protected]
PMID: 11454465 DOI: 10.1016/s0960-894x(01)00352-3
Abstract

The synthesis and Antiviral evaluation of unsymmetrical indolocarbazole derivatives of Arcyriaflavin A, substituted with a range of alkyl groups at the indole nitrogen, is described. Structure-activity relationships in this series against human cytomegalovirus (HCMV) replication in Cell Culture are reported. Compound 4b was identified as potent inhibitor of HCMV (IC(50)=19 nM), which retained activity against a range of HCMV strains including ganciclovir resistant isolates.