Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors

  • Bioorg Med Chem Lett. 2005 Mar 15;15(6):1693-5. doi: 10.1016/j.bmcl.2005.01.050.
Guy Falardeau  1 ,  Hugo Lachance ,  Annie St-Pierre ,  Constantin G Yannopoulos ,  Marc Drouin ,  Jean Bédard ,  Laval Chan
Affiliations
  • 1. ViroChem Pharma Inc., 275 Armand-Frappier Blvd., Laval, Québec, Canada H7V 4A7. [email protected]
PMID: 15745823 DOI: 10.1016/j.bmcl.2005.01.050
Abstract

A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2.