A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity

  • Antimicrob Agents Chemother. 2009 Jan;53(1):312-5. doi: 10.1128/AAC.00988-08.
Beatrice Mercorelli  1 ,  Giulia Muratore ,  Elisa Sinigalia ,  Oriana Tabarrini ,  Maria Angela Biasolo ,  Violetta Cecchetti ,  Giorgio Palù ,  Arianna Loregian
Affiliations
  • 1. Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padua, Italy.
PMID: 19015358 DOI: 10.1128/AAC.00988-08
Abstract

We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of approximately 500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was approximately 10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.