Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition

  • Bioorg Med Chem Lett. 2008 Jul 15;18(14):3856-9. doi: 10.1016/j.bmcl.2008.06.060.
Mark E Schnute  1 ,  Roger J Brideau ,  Sarah A Collier ,  Michele M Cudahy ,  Todd A Hopkins ,  Mary L Knechtel ,  Nancee L Oien ,  Robert S Sackett ,  Allen Scott ,  Mari L Stephan ,  Michael W Wathen ,  Janet L Wieber
Affiliations
  • 1. Global Research and Development, Pfizer Inc., 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. [email protected]
PMID: 18595689 DOI: 10.1016/j.bmcl.2008.06.060
Abstract

A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.