Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents

  • J Med Chem. 2015 Nov 12;58(21):8734-8. doi: 10.1021/acs.jmedchem.5b00804.
Pramod K Sahu  1 ,  Tamima Umme  2 ,  Jinha Yu  1 ,  Akshata Nayak  1  2 ,  Gyudong Kim  1 ,  Minsoo Noh  1 ,  Jae-Young Lee  1 ,  Dae-Duk Kim  1 ,  Lak Shin Jeong  1
Affiliations
  • 1. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
  • 2. College of Pharmacy, Ewha Womans University , Seoul 120-750, Korea.
PMID: 26460883 DOI: 10.1021/acs.jmedchem.5b00804
Abstract

On the basis of the potent Antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new Antiviral agents.