Selnoflast monopotassium
Based on 1 publication(s) in Google Scholar
Selnoflast (RO7486967) monopotassium, formerly somalix/RG6418/IZD334 monopotassium, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast monopotassium is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast monopotassium is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease.
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- CAS 番号: 2260969-37-5
- 分子式: C20H28KN3O3S
- 分子量:429.62
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Selnoflast monopotassium
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生物活性
製品説明
IC50 & Target
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NLRP3 |
化学情報
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CAS 番号 2260969-37-5
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分子量 429.62
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分子式 C20H28KN3O3S
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SMILES
O=C([N-]S(=O)(C1CCN(CC)CC1)=O)NC2=C(CCC3)C3=CC4=C2CCC4.[K+]
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別名
Somalix monopotassium; RO-7486967 monopotassium; IZD334 monopotassium
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Chem Biol
Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays. [Abstract]2024 Feb 15;31(2):349-360.e6. PMID: 37858335
純度とドキュメンテーション
参考文献
[1]. Klughammer B, et al. A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis. Clin Transl Med. 2023 Nov;13(11):e1471. [Content Brief]
[2]. Vande Walle L, et al. Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets. Nat Rev Drug Discov. 2023 Nov 29. [Content Brief]
[3]. Silvis MJM, et al., NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction. Biomedicines. 2022 Nov 28;10(12):3056. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Selnoflast monopotassium 関連分類
HY-132831C 関連分類
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Keywords
- Selnoflast monopotassium
- 2260969-37-5
- Somalix monopotassium
- RO-7486967 monopotassium
- IZD334 monopotassium
- NOD-like Receptor (NLR)
- Interleukin Related
- orally active
- reversible
- NLRP3 inhibitor
- IL-1β inhibitor
- Alzheimer's disease
- ulcerative colitis
- chronic obstructive pulmonary disease
- macrophages
- Inhibitor
- inhibitor
- inhibit