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Cat. No.: HY-132831A

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Selnoflast calcium

(Synonyms: Somalix calcium; RO-7486967 calcium; IZD334 calcium)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Selnoflast calcium (RO7486967 calcium), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast calcium is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast calcium is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease.

For research use only. We do not sell to patients.

CAS No.: 2887416-19-3
Formula: C₂₀H₂₉N₃O₃S.xCa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Selnoflast calcium Chemical Structure

CAS No.: 2887416-19-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

In Vitro

Selnoflast calcium (0.1-10 µM) inhibits the LPS (HY-D1056)-induced IL-1β release in porcine peripheral blood mononuclear cells (PBMCs) with an IC₅₀ of 0.35 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2887416-19-3
Formula C₂₀H₂₉N₃O₃S.xCa
SMILES

O=C(NS(=O)(C1CCN(CC1)CC)=O)NC2=C(CCC3)C3=CC4=C2CCC4.[x].[Ca]
Synonyms

Somalix calcium; RO-7486967 calcium; IZD334 calcium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Cell Chem Biol

Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays. [Abstract]

2024 Feb 15;31(2):349-360.e6. PMID: 37858335

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vande Walle L, et al. Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets. Nat Rev Drug Discov. 2023 Nov 29. [Content Brief]

[2]. Klughammer B, et al. A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis. Clin Transl Med. 2023 Nov;13(11):e1471. [Content Brief]

[3]. Silvis MJM, et al., NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction. Biomedicines. 2022 Nov 28;10(12):3056. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Selnoflast calcium

1 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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Selnoflast calcium

Publications Citing Use of MedChemExpress (MCE) Selnoflast calcium

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Selnoflast calcium Related Classifications

HY-132831A Related Classifications