Fmoc-D-cyclohexylalanine

Fmoc-D-cyclohexylalanine is a Dnase1L3 inhibitor. Fmoc-D-cyclohexylalanine targets the calcium/magnesium-dependent endonuclease Dnase1L3 essential for inflammasome function, inhibiting its endonuclease activity and DNA degradation. Fmoc-D-cyclohexylalanine interferes with processes such as ASC nuclear transport and speck formation, blocking NLRP3/NLRC4-dependent caspase-1 activation, IL-1β maturation, and the release of alarmins such as HMGB1, without directly inhibiting caspase-1 or affecting TNF-α secretion. Fmoc-D-cyclohexylalanine mildly inhibits pyroptosis while strongly blocking inflammasome-dependent cytokine secretion, uncoupling this secretion from pyroptosis.

• Data Sheet (287 KB)
• Custom Peptide Synthesis