1. NF-κB
    Immunology/Inflammation
  2. NF-κB
    NOD-like Receptor (NLR)
  3. CORM-3

CORM-3 

Cat. No.: HY-100581 Purity: >92.0%
Handling Instructions

CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation.

For research use only. We do not sell to patients.

CORM-3 Chemical Structure

CORM-3 Chemical Structure

CAS No. : 475473-26-8

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1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
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Description

CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation[1][2][3].

IC50 & Target

NLRP3

 

In Vitro

CORM-3 suppresses caspase-1 activation and the secretion of interleukin (IL)-1β and IL-18 in macrophages in response to lipopolysaccharide (LPS) and ATP. CORM-3 inhibits the oligomerization of the adaptor protein apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which is required for NLRP3-dependent caspase-1 activation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CORM-3 (4 mg/kg, ip) reduces NLRP3 inflammasome activation and inhibits hyperglycemia-induced inflammation in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT mice (C57BL/6J male, 8e10 weeks old)[2].
Dosage: 4 mg/kg.
Administration: IP for 3 h before i.p. injection of E. coli LPS (10 mg/kg), and IP injection after 7-day-treatment of S0130.
Result: Resulted in significantly lower plasma levels of IL-1β and IL-18 in response to LPS challenge in vivo in WT mice relative to that in vehicle-treated control mice, whereas TNF-a levels were unchanged.
Had lower expression of cleaved caspase-1 and cleaved IL-1b in response to ATP and nigericin, relative to vehicle control, whereas the expression of procaspase-1 and pro-IL-1β expression was unchanged.
Molecular Weight

294.61

Formula

C₅H₄ClNO₅Ru

CAS No.

475473-26-8

SMILES

O#C[Ru+2](C#O)([Cl-])([O-]C1=O)([N]([H])([H])C1)C#O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (407.32 mM; Need ultrasonic)

H2O : 50 mg/mL (169.72 mM; Need ultrasonic)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3943 mL 16.9716 mL 33.9432 mL
5 mM 0.6789 mL 3.3943 mL 6.7886 mL
10 mM 0.3394 mL 1.6972 mL 3.3943 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >92.0%

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Keywords:

CORM-3CORM3CORM 3NF-κBNOD-like Receptor (NLR)Nuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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CORM-3
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HY-100581
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