NP3-146
NP3-146 is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 shows potent inhibitory activity against IL-1β release with an IC50 value of 0.171 μM in LPS (HY-D1056)/Nigericin (HY-127019)-stimulated BMDM cells. NP3-146 regulates the levels of cleaved Caspase-1 and cleaved IL-1β in cell supernatants. NP3-146 can be used for the research of inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 210826-47-4
- Formula: C20H27ClN2O5S
- Molecular Weight:442.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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NLRP3 |
NP3-146 (1-10000 nM) significantly inhibits IL-1β release with an IC50 value of 171 nM[1].
NP3-146 (0.05-0.5 μM) regulates the levels of cleaved Caspase-1 and cleaved IL-1β in cell supernatants of the BMDM cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 210826-47-4
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Molecular Weight 442.96
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Formula C20H27ClN2O5S
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SMILES
O=C(NS(=O)(C1=CC(C(C)(C)O)=CO1)=O)NC2=C(C(C)C)C=C(Cl)C=C2C(C)C
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Synonyms
NLRP3-IN-5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Feng H, et al. Design, synthesis and biological evaluation of sulfonylurea derivatives as NLRP3 inflammasome inhibitors. Bioorg Med Chem Lett. 2024 Dec 1;114:129987. [Content Brief]
[2]. Harrison D, et al. Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors. ACS Med Chem Lett. 2022 Aug 1;13(8):1321-1328. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NP3-146 Related Classifications
HY-145087 Related Classifications
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