1. MAPK/ERK Pathway
  2. Mixed Lineage Kinase
  3. (E)-Necrosulfonamide

(E)-Necrosulfonamide 

Cat. No.: HY-100573 Purity: 99.23%
Handling Instructions

(E)-Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL) to block the necrosome formation.

For research use only. We do not sell to patients.

(E)-Necrosulfonamide Chemical Structure

(E)-Necrosulfonamide Chemical Structure

CAS No. : 1360614-48-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
25 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 264 In-stock
Estimated Time of Arrival: December 31
100 mg USD 480 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

(E)-Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL) to block the necrosome formation.

Molecular Weight

461.47

Formula

C₁₈H₁₅N₅O₆S₂

CAS No.

1360614-48-7

SMILES

O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3.[(E)]

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 28 mg/mL (60.68 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1670 mL 10.8349 mL 21.6699 mL
5 mM 0.4334 mL 2.1670 mL 4.3340 mL
10 mM 0.2167 mL 1.0835 mL 2.1670 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.23%

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Product Name:
(E)-Necrosulfonamide
Cat. No.:
HY-100573
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