1. MAPK/ERK Pathway
  2. Mixed Lineage Kinase

Necrosulfonamide 

Cat. No.: HY-100573 Purity: 98.00%
Handling Instructions

Necrosulfonamide is a pharmacological inhibitor of MLKL with IC50 values of 124 nM in human HT-29.

For research use only. We do not sell to patients.

Necrosulfonamide Chemical Structure

Necrosulfonamide Chemical Structure

CAS No. : 1360614-48-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
25 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 264 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 480 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Featured Recommendations

Related Small Molecules:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Necrosulfonamide is a pharmacological inhibitor of MLKL with IC50 values of 124 nM in human HT-29. target: MLKL[1] IC50 : 124 nM. In vitro: Necrosulfonamide significantly decreases BV6/DAC-induced cell death in MV4-11 cells.[1] Treating cells with necrosulfonamide or knocking down MLKL expression arrests necrosis at a specific step at which RIP3 formed discrete punctae in cells. necrosulfonamide had no effect on apoptosis induced by TNF-α plus Smac mimetic in non-RIP3-expressing Panc-1 cells.[2] Complete inhibition was observed at NSA concentration of 0.5 ?M. NSA is also an effective inhibitor of the necroptotic pathway induced by STS in the presence of caspase inhibitor. [3]

References
Molecular Weight

461.47

Formula

C₁₈H₁₅N₅O₆S₂

CAS No.

1360614-48-7

SMILES

O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 28 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.00%

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Necrosulfonamide
Cat. No.:
HY-100573
Quantity: