Necrosulfonamide-d₄

Name: Necrosulfonamide-d 4
Brand: MedChemExpress
SKU: HY-100573S
Rating: 4.5 (1 reviews)

Cat. No.: HY-100573S Purity: 99.26%: FAQs
Data Sheet SDS COA Handling Instructions

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Necrosulfonamide-d₄ is the deuterium labeled Necrosulfonamide. Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis.

For research use only. We do not sell to patients.

Necrosulfonamide-d<sub>4</sub> Chemical Structure

Necrosulfonamide-d₄ Chemical Structure

CAS No. : 1795144-22-7

Size	Price	Stock	Quantity
1 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Necrosulfonamide-d₄:

Necrosulfonamide In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

465.50

Formula

C₁₈H₁₁D₄N₅O₆S₂

CAS No.

1795144-22-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=NC=CN=C1NS(=O)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])NC(/C=C/C3=CC=C([N+]([O-])=O)S3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (214.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1482 mL	10.7411 mL	21.4823 mL
5 mM	0.4296 mL	2.1482 mL	4.2965 mL
10 mM	0.2148 mL	1.0741 mL	2.1482 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.26%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (248 KB) HNMR (140 KB) RP-HPLC (244 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148(1-2):213-227. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1482 mL	10.7411 mL	21.4823 mL	53.7057 mL
	5 mM	0.4296 mL	2.1482 mL	4.2965 mL	10.7411 mL
	10 mM	0.2148 mL	1.0741 mL	2.1482 mL	5.3706 mL
	15 mM	0.1432 mL	0.7161 mL	1.4322 mL	3.5804 mL
	20 mM	0.1074 mL	0.5371 mL	1.0741 mL	2.6853 mL
	25 mM	0.0859 mL	0.4296 mL	0.8593 mL	2.1482 mL
	30 mM	0.0716 mL	0.3580 mL	0.7161 mL	1.7902 mL
	40 mM	0.0537 mL	0.2685 mL	0.5371 mL	1.3426 mL
	50 mM	0.0430 mL	0.2148 mL	0.4296 mL	1.0741 mL
	60 mM	0.0358 mL	0.1790 mL	0.3580 mL	0.8951 mL
	80 mM	0.0269 mL	0.1343 mL	0.2685 mL	0.6713 mL
	100 mM	0.0215 mL	0.1074 mL	0.2148 mL	0.5371 mL