Yadanzigan
Yadanzigan (YDZG) is an anti-inflammatory agent and a NLRP3 inhibitor. Yadanzigan specifically inhibits NLRP3 activation via inhibiting NF-κB pathway and Reactive Oxygen Species production. Yadanzigan also moderates LPS (HY-D1056)-induced acute lung injury (ALI) in mice.
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- No. CAS: 76588-87-9
- Fòrmula: C26H38O14
- Peso molecular:574.57
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
NLRP3 inflammasome |
In Vitro
Yadanzigan (20, 40, and 80 μM; 1 h) promotes Nrf2 translocation from the cytoplasm into the nucleus in RAW264.7 macrophages[1].
Yadanzigan (20 μM; 1 h) suppresses mitochondrial reactive oxygen species (ROS) generation in HEK293T cells induced by LPS (1 μg/mL; 6 h)[1].
Yadanzigan (40 μM; 1 h) significantly blocks the formation of the NLRP3 inflammasome in J774A.1 cells induce by LPS and ATP[1].
Yadanzigan (2.5-10 μM or 10-40 μM; 1, 6, 12 h) enhances TRIM31 expression to promote NLRP3 protein degradation in J774A.1, and THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774A.1, and THP-1 cells
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Concentration:For J774A.1: 2.5 μM, 5 μM, and 10 μM; For THP-1: 10 μM, 20 μM, and 40 μM
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Incubation Time:For J774A.1: 6 h, 12 h; For THP-1: 1 hour; 2 h before 1 μg/mL LPS stimulated and another 30 min before 5 mM ATP induced
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Result:Led to a sharp decrease in NLRP3 expression in J774A.1 cells.
Led to a large decrease in NLRP3 protein expression in a dose-dependent manner in THP-1 cells.
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Cell Line:RAW264.7 macrophages, THP-1 cells
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Concentration:20, 40, and 80 μM
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Incubation Time:Pre-treated for 1 h, continue to incubate for 18 h
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Result:Decreased caspase-1 p20 activation and mature IL-1β and inhibited cleaved caspase-1 release into supernatants.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BABL/C mice (18-22 g)[1]
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Dosage:5 mg/kg, 10 mg/kg
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Administration:Intravenous injection; dose at 2 h prior to and 6 h, 12 h after LPS induction
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Result:Reduced LPS-induced infiltration of inflammatory cells and cytokine levels, such as TNF-α and IL-6. Inhibited NLRP3 inflammasome activation in lung tissue.
Resulted significantly greater survival rate.
Chemical Information
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No. CAS 76588-87-9
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Peso molecular 574.57
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Fòrmula C26H38O14
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SMILES
CC1=C[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@@H](O)[C@@]3(C)[C@H]1C[C@@H]4[C@]56[C@@H]3[C@@H](O)[C@H](O)[C@@](OC6)(C)[C@]5(O)[C@@H](O)C(O4)=O
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Synonyms
YDZG
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Yadanzigan Related Classifications
HY-N10312 Related Classifications
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