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Cat. No.: HY-186403

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VVD-124476

Name: VVD-124476
Brand: MedChemExpress
SKU: HY-186403
Availability: PreOrder

(Synonyms: MY-1A)

VVD-124476 (MY-1A) is a covalent NLRP3 binder. VVD-124476 binds to the Cys463 cysteine residue of the NLRP3 protein and exhibits moderate target-binding activity. VVD-124476 covalently modifies NLRP3, but the molecule shows substantial off-target cysteine modification overall and poor selectivity, making it unsuitable for cell-level functional studies. VVD-124476 can be used in research related to chemical proteomic probes for the NLRP3 target.

For research use only. We do not sell to patients.

CAS No.: 2929308-16-5
Formula: C₂₂H₁₈BrN₃O₂
Molecular Weight:436.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

VVD-124476 Chemical Structure

CAS No.: 2929308-16-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

NLRP3

All NOD-like Receptor (NLR) Isoforms :

In Vitro

Inflammasome

VVD-124476 (MY-1A) binds to NLRP3_C463 in OCI-AML2 cell lysates with a TE₅₀ of 7.4 μM, but is highly promiscuous, with P₅₀₀ = 20.5%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2929308-16-5
Molecular Weight 436.30
Formula C₂₂H₁₈BrN₃O₂
SMILES

O=C([C@@H]1[C@H](C2=CC=C(C=C2)Br)CN1C(C=C)=O)NC3=CC=CC4=C3N=CC=C4
Synonyms

MY-1A
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. La Monica G, et al. 6-Chloropyridinyl Benzoate Fragments as Selective Anti-Melanoma Scaffolds Triggering ROS-Mediated Mitochondrial Apoptosis. ACS Omega, 2026, 11 (42): 65020-65034.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VVD-124476

All NOD-like Receptor (NLR) Isoforms