2. PROTAC Cell Cycle/DNA Damage Apoptosis Immunology/Inflammation
  3. Molecular Glues NEKs NOD-like Receptor (NLR) Caspase Interleukin Related
  4. NEK7 degrader-1

NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 9  nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research.

For research use only. We do not sell to patients.

NEK7 degrader-1

NEK7 degrader-1 Chemical Structure

CAS No. : 3069891-91-1

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NEK7 degrader-1 Related Antibodies

Top Publications Citing Use of Products

View All NEKs Isoform Specific Products:

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NEK1 NEK2 NEK4 NEK6 NEK7

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NLRP3 NLRP1 NOD1 NOD2

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 9  nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].

IC50 & Target[1]

Caspase-1

 

IL-1β

 

NEK7

9 nM (DC50)

NLRP3 inflammasome

 

In Vitro

NEK7 degrader-1 (Compound 14) dose-dependently inhibits caspase-1 activity (IC50 of 1.85 nM) and IL-Ιβ release (IC50 of 1.95 nM) in macrophages in response to NLRP3 inflammasome activation[1].
NLRP3 modulator 8 (Compound 14) binds to CRBN by HTRF assay with an EC50 value of 0.11μM

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NEK7 degrader-1 Related Antibodies
Molecular Weight

449.33

Formula

C21H22Cl2N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C)C=N3)=O)C=C2Cl)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (222.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2255 mL 11.1277 mL 22.2554 mL
5 mM 0.4451 mL 2.2255 mL 4.4511 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

SDS (251 KB)

COA (248 KB) HNMR (246 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2255 mL 11.1277 mL 22.2554 mL 55.6384 mL
5 mM 0.4451 mL 2.2255 mL 4.4511 mL 11.1277 mL
10 mM 0.2226 mL 1.1128 mL 2.2255 mL 5.5638 mL
15 mM 0.1484 mL 0.7418 mL 1.4837 mL 3.7092 mL
20 mM 0.1113 mL 0.5564 mL 1.1128 mL 2.7819 mL
25 mM 0.0890 mL 0.4451 mL 0.8902 mL 2.2255 mL
30 mM 0.0742 mL 0.3709 mL 0.7418 mL 1.8546 mL
40 mM 0.0556 mL 0.2782 mL 0.5564 mL 1.3910 mL
50 mM 0.0445 mL 0.2226 mL 0.4451 mL 1.1128 mL
60 mM 0.0371 mL 0.1855 mL 0.3709 mL 0.9273 mL
80 mM 0.0278 mL 0.1391 mL 0.2782 mL 0.6955 mL
100 mM 0.0223 mL 0.1113 mL 0.2226 mL 0.5564 mL
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NEK7 degrader-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NEK7 degrader-13069891-91-1Molecular GluesNEKsNOD-like Receptor (NLR)CaspaseInterleukin RelatedNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed KinasesILNEK7NLRP3 inflammasomeMultiple sclerosisAlzheimer's diseasePericarditisType 2 diabetesInhibitorinhibitorinhibit

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