3069891-91-1
Chemical Structure
NEK7 degrader-1
- CAS No.: 3069891-91-1
- Formula:C21H22Cl2N4O3
- Molecular Weight:449.33
InChIKey: VKROEWYACWPSOG-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C)C=N3)=O)C=C2Cl)Cl)=O
Biological Activity: NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 9 nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NEK7 degrader-1 | 99.94% | NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 9 nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research. | ||||||||||||||||||||
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Keywords
