NLRP3-IN-99
NLRP3-IN-99 is an orally active NLRP3 inflammasome inhibitor, IC50 = 0.019 μM. NLRP3-IN-99 binds to the NLRP3 NACHT domain with a human Kd value of 6.9 nM, blocking inflammasome assembly and activation. NLRP3-IN-99 blocks ASC oligomerization and the assembly of NLRP3 with ASC and NEK7, inhibiting NLRP3-driven IL‑1β secretion. NLRP3-IN-99 can be used for research on NLRP3-related diseases, such as gout.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3107107-66-1
- Formel: C27H26N2O5S
- Molecular Weight:490.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
NLRP3 0.019 μM (IC50) |
NLRP3 6.9 nM (Kd) |
IL-1β |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| THP-1 | IC50 |
0.019 μM
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Inhibition of IL-1β release in LPS + MSU-stimulated human THP-1-M macrophages after 30 min compound pre-incubation followed by 4 hrs MSU stimulation measured by ELISA.
Inhibition of IL-1β release in LPS + MSU-stimulated human THP-1-M macrophages after 30 min compound pre-incubation followed by 4 hrs MSU stimulation measured by ELISA.
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39302813 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T cell
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Concentration:0.39, 0.78, 1.56, 3.13, 6.25, 12.5, 25, 50, 100 μM
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Incubation Time:24 h
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Result:Exhibited low cytotoxicity in HEK293T cells.
Chemical Information
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CAS. Nr. 3107107-66-1
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Molecular Weight 490.57
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Formel C27H26N2O5S
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SMILES
O=C(NS(=O)(C1=CC(C(C)(C)O)=CO1)=O)NC2=C(C3=CC4=C(C=CC=C4)C=C3)C=CC5=C2CCC5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NLRP3-IN-99 Related Classifications
HY-186376 Related Classifications
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