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Cat. No.: HY-182778

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Anti-inflammatory agent 114

Anti-inflammatory agent 114 is an anti-inflammatory agent. Anti-inflammatory agent 114 binds to the allosteric inhibitory pocket in the NLRP3 NACHT domain. Anti-inflammatory agent 114 inhibits the expression of iNOS, COX-2 and NLRP3. Anti-inflammatory agent 114 can be used for the research of inflammatory diseases.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₆O₆
Molecular Weight:434.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anti-inflammatory agent 114 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

NLRP3

COX-2

All NOD-like Receptor (NLR) Isoforms :

All COX Isoforms :

All NO Synthase Isoforms :

In Vitro

Anti-inflammatory agent 114 (compound 1i) (10 μM; 24 h) potently inhibits NO production in LPS (HY-D1056)-stimulated RAW264.7 macrophages^[1].
Anti-inflammatory agent 114 (10 μM; 24 h) potently inhibits the protein expression of iNOS, COX-2 and NLRP3 in LPS-stimulated RAW264.7 macrophages^[1].
Anti-inflammatory agent 114 (0.63-10 μM; 24 h) dose-dependently inhibits the protein expression of iNOS, COX-2 and NLRP3 in LPS-stimulated RAW264.7 macrophages, with the strongest inhibitory effect observed at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

RAW264.7 macrophages treated LPS
Concentration:

0.63, 1.25, 2.5, 5, 10 μM
Incubation Time:

24 h
Result:

Suppressed the expression of iNOS, COX-2, and NLRP3 proteins in a concentration-dependent manner.

Chemical Information

Molecular Weight 434.48
Formula C₂₆H₂₆O₆
SMILES

OC1=C(C(/C=C/C2=CC=C(C3=CC(OC)=C(OC)C(OC)=C3)C=C2)=O)C=C(C)C(OC)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang B, et al. Design and synthesis of sorbicillinoid-derived bibenzyl and brominated analogues as anti-inflammatory agents. Bioorg Med Chem Lett. Published online March 30, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Anti-inflammatory agent 114

All NOD-like Receptor (NLR) Isoforms

All COX Isoforms

All NO Synthase Isoforms