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ATP disodium salt, 100 mM Solution, PCR Grade

(Synonyms: Adenosine 5'-triphosphate disodium salt, 100 mM Solution, PCR Grade)
164 Cited Publications
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Based on 164 publication(s) in Google Scholar

ATP (Adenosine 5'-triphosphate) disodium salt, 100 mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100 mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100 mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100 mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100 mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

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  • CAS No.: 987-65-5
  • Formula: C10H14N5Na2O13P3
  • Molecular Weight:551.14
  • Storage:

    Solution, -20°C, 2 years

  • ATP disodium salt, 100 mM Solution, PCR Grade Chemical Structure
    ATP disodium salt, 100 mM Solution, PCR Grade Chemical Structure
  • Experimental Validation Results for ATP disodium salt, 100 mM Solution, PCR Grade
  • Experimental Validation Results for ATP disodium salt, 100 mM Solution, PCR Grade
  • Experimental Validation Results for ATP disodium salt, 100 mM Solution, PCR Grade
  • Experimental Validation Results for ATP disodium salt, 100 mM Solution, PCR Grade
  • Experimental Validation Results for ATP disodium salt, 100 mM Solution, PCR Grade
  • Experimental Validation Results for ATP disodium salt, 100 mM Solution, PCR Grade
CAS No.: 987-65-5
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WBCell Proliferation/Viability AssayRT-PCR
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All Endogenous Metabolite Isoforms

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All NOD-like Receptor (NLR) Isoforms

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  • ATP disodium salt, 100 mM Solution, PCR Grade Chemical Structure
    ATP disodium salt, 100 mM Solution, PCR Grade Chemical Structure
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    ATP disodium salt, 100 mM Solution, PCR Grade purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Mar 12;57(3):495-512.e11. [Abstract]

    Customer Validation
     Representative western blots and analyses of the following proteins in BV2 cells treated with vehicle (Con), LPS (200 ng/ml, 3 h), LPS + ATP (3 mM, 30 min), or LPS + ATP-siNKAα1.

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    ATP disodium salt, 100 mM Solution, PCR Grade purchased from MedChemExpress. Usage Cited in: Transl Res. 2023 May:255:1-13. [Abstract]

    Customer Validation
     LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.

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    ATP disodium salt, 100 mM Solution, PCR Grade purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2022 Feb;29(2):439-450. [Abstract]

    Customer Validation
     Primary BMDM cells were isolated from WT and Trim21-/- C57BL/6 mice. Cells were primed with 1 μg/mL LPS for 2 h followed by 5 mM ATP or 20 μM Nig or 30 μM flagellin for 30 min. Cell viability are determined by the Cell Counting Kit-8.

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    ATP disodium salt, 100 mM Solution, PCR Grade purchased from MedChemExpress. Usage Cited in: Crit Care. 2021 Oct 12;25(1):356. [Abstract]

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     Stimulation of Raw264.7 macrophages with PBS/PBS-Exo/TNF-Exo for 24 h and treatment with PBS, 5 mM ATP or 20 mM nigericin for 2 h. Cleavage of GSDMD by western blot. GSDMD-FL: full-length GSDMD, GSDMD-N: N-terminal cleavage products of GSDMD.

  • 1/16

    ATP disodium salt, 100 mM Solution, PCR Grade purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132.  [Abstract]

    Customer Validation
     KCs were stimulated with 100 ng/mL LPS for 4 hours and subsequently treated them with 5 mM ATP for 2 hours to induce pyroptosis. The RNA level of lnc-Lfar1 was determined by qRT-PCR.

  • 1/16

    ATP disodium salt, 100 mM Solution, PCR Grade purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132.  [Abstract]

    Customer Validation
     KCs were transfected with lnc-Lfar1 siRNA for 24 h, followed by stimulation with 100 ng/ml LPS for 4 h and subsequently treated with 5 mM ATP or 100 ng/ml for 2 h to induce pyroptosis. a, b The protein level of NLRP3, Caspase1 and GSDMD was determined by western blot. GAPDH was used as an internal control.

  • ATP disodium salt, 100 mM Solution, PCR Grade