NLRP3-IN-81
NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM against cell pyroptosis induced by Nigericin (HY-127019). NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 2922814-85-3
- Formula: C16H15F3N2O3S
- Molecular Weight:372.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
|
Caspase-1 |
IL-1β |
NLRP3 inflammasome 0.029 μM (EC50) |
| Species | Dose | Route | AUC0-t | MRT0-t | Tmax | T1/2 | Cmax | CL |
|---|---|---|---|---|---|---|---|---|
| Mice | 1 mg/kg | i.v. | 32710 ng/L.h | 0.07 h | 0.03 h | 0.06 h | 299.4 μg/L | 31.89 L/h/kg |
| Mice | 10 mg/kg | i.p. | 65180 ng/L.h | 23.15 h | 0.08 h | 0.33 h | 173.83 μg/L | 152.46 L/h/kg |
Chemical Information
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CAS No. 2922814-85-3
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Molecular Weight 372.36
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Formula C16H15F3N2O3S
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SMILES
O=S(C1=NN=C(C=C1)C2=C(C=C(C=C2)C(F)(F)F)O)(C3CCCC3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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