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Cat. No.: HY-163358

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SLC3037

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. SLC3037 can be used for research of gout, cardiovascular diseases, metabolic syndrome or neurodegenerative diseases.

For research use only. We do not sell to patients.

Purity: 99.85%
Formula: C₂₉H₃₅N₇OS
Molecular Weight:529.70

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SLC3037 Chemical Structure

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

NLRP3

NEK7

All NOD-like Receptor (NLR) Isoforms :

All NEKs Isoforms :

In Vitro

SLC3037 (1-10 μM, 5 h) inhibits the IL-1β induced by LPS and MSU dose-dependently in BMDMs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 529.70
Formula C₂₉H₃₅N₇OS
Color Light yellow to yellow
SMILES

CN(CCNC(C1=CC(C2=CSC3=C2N=C(N=C3)NC4=CC=C(C=C4)N5CCN(CC5)CC)=CC=C1)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Mol Cell

Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation. [Abstract]

2024 Aug 18:S1097-2765(24)00633-6. PMID: 39173637

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (377.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8879 mL

9.4393 mL

18.8786 mL

5 mM

0.3776 mL

1.8879 mL

3.7757 mL

10 mM

0.1888 mL

0.9439 mL

1.8879 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Park K, et al. A novel NLRP3 inhibitor as a therapeutic agent against monosodium urate-induced gout. Front Immunol. 2024 Feb 2;14:1307739. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8879 mL	9.4393 mL	18.8786 mL	47.1965 mL
	5 mM	0.3776 mL	1.8879 mL	3.7757 mL	9.4393 mL
	10 mM	0.1888 mL	0.9439 mL	1.8879 mL	4.7197 mL
	15 mM	0.1259 mL	0.6293 mL	1.2586 mL	3.1464 mL
	20 mM	0.0944 mL	0.4720 mL	0.9439 mL	2.3598 mL
	25 mM	0.0755 mL	0.3776 mL	0.7551 mL	1.8879 mL
	30 mM	0.0629 mL	0.3146 mL	0.6293 mL	1.5732 mL
	40 mM	0.0472 mL	0.2360 mL	0.4720 mL	1.1799 mL
	50 mM	0.0378 mL	0.1888 mL	0.3776 mL	0.9439 mL
	60 mM	0.0315 mL	0.1573 mL	0.3146 mL	0.7866 mL
	80 mM	0.0236 mL	0.1180 mL	0.2360 mL	0.5900 mL
	100 mM	0.0189 mL	0.0944 mL	0.1888 mL	0.4720 mL

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

Product Name:
Cat. No.:
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MCE Japan Authorized Agent:

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CAS No.:
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SLC3037

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

NF-κB Signaling Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Pyroptosis Compound Library

Neurodegenerative Disease-related Compound Library

Antidepressant Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Inflammasomes related Compound Library

Multi-Target Compound Library

Radioprotector Library

Mitophagy Compound Library

Bioactive Compound Library Max

Anti-Aging Compound Library Mini

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Pattern Recognition Receptors Library

Publications Citing Use of MedChemExpress (MCE) SLC3037

All NOD-like Receptor (NLR) Isoforms

All NEKs Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

SLC3037

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

NF-κB Signaling Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Pyroptosis Compound Library

Neurodegenerative Disease-related Compound Library

Antidepressant Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Inflammasomes related Compound Library

Multi-Target Compound Library

Radioprotector Library

Mitophagy Compound Library

Bioactive Compound Library Max

Anti-Aging Compound Library Mini

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Pattern Recognition Receptors Library

Publications Citing Use of MedChemExpress (MCE) SLC3037

All NOD-like Receptor (NLR) Isoforms

All NEKs Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

SLC3037 Related Classifications

Cat. No.: HY-163358