1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. (±)11(12)-EET

(±)11(12)-EET (Synonyms: 11,12-EET)

Cat. No.: HY-130494
Handling Instructions

(±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective.

For research use only. We do not sell to patients.

(±)11(12)-EET Chemical Structure

(±)11(12)-EET Chemical Structure

CAS No. : 123931-40-8

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Description

(±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective[1][2][3][4][6].

IC50 & Target[1]

NLRP3 inflammasome

 

In Vitro

(±)11(12)-EET (5 μM; 10 mimutes; macrophages) depresses NLRP3 protein expression, dramatically decreases the expression of pro-IL-1β in cells and the supernatant and reduces the intracellular ROS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Macrophages
Concentration: 5 μM
Incubation Time: 10 mimutes
Result: Depresses NLRP3 protein expression.

Immunofluorescence[1]

Cell Line: Macrophages
Concentration: 5 μM
Incubation Time: 10 mimutes
Result: Reduced the intracellular ROS.
In Vivo

(±)11(12)-EET increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 in 50 µg/kg[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

320.47

Formula

C₂₀H₃₂O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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(±)11(12)-EET
Cat. No.:
HY-130494
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