87173-81-7
87173-81-7
Chemical Structure
(±)11(12)-EET
Synonym(s): 11,12-EET
- CAS. Nr.: 87173-81-7
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: (5Z,8Z)-10-((2S,3R)-3-((Z)-oct-2-en-1-yl)oxiran-2-yl)deca-5,8-dienoic acid
InChIKey: DXOYQVHGIODESM-LZXKBWHHSA-N
SMILES: CCCCC/C=C\C[C@H]1O[C@H]1C/C=C\C/C=C\CCCC(O)=O
Biological Activity: (±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective[1][2][3][4][6].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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(±)11(12)-EET | 98.33% | (±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective. | ||||||||||||||||||||
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(±)11(12)-EET-d11 | 98.01% | (±)11(12)-EET-d11 is the deuterium labeled (±)11(12)-EET. (±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective. | ||||||||||||||||||||
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References
- [1]. Luo XQ, et al. Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages. J Cell Physiol. 2020;235(12):9910-9921. [Content Brief]
- [2]. Chacos N, et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun. 1982;104(3):916-922. [Content Brief]
- [3]. Oliw EH, et al. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem. 1982;257(7):3771-3781. [Content Brief]
- [4]. Capdevila JH, et al. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41(2):163-181. [Content Brief]
- [6]. Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res. 2009;50 Suppl(Suppl):S52-S56. [Content Brief]
