NLRP3-IN-95
NLRP3-IN-95 is an NLRP3 inflammasome inhibitor with an IC50 of 27 nM. NLRP3-IN-95 inhibits IL-1β secretion in PMA-differentiated THP-1 cells. NLRP3-IN-95 can be used in studies related to acute monocytic leukemia and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 2771021-30-6
- Formula: C16H11F4IN4O2
- Molecular Weight:494.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NLRP3 inflammasome 27 nM (IC50) |
NLRP3-IN-95 (compound 301) (1 h pretreatment, 2 h LPS (HY-D1056A1) + Nigericin (HY-127019) stimulation) inhibits IL-1β secretion in the supernatant of PMA-differentiated THP-1 cells with an IC50 of 27 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2771021-30-6
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Molecular Weight 494.18
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Formula C16H11F4IN4O2
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SMILES
O=C(CN1C(C2=CC=C(C=C2C(C(F)(F)F)C1)I)=O)NC3=NC=C(C=N3)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-95 Related Classifications
HY-184882 Related Classifications
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- NLRP3-IN-95
- 2771021-30-6
- NOD-like Receptor (NLR)
- NLRP3
- NLRP3 inflammasome
- IL-1β
- IL-18
- THP-1 cells
- PMA-differentiation
- LPS
- Nigericin
- IL-1β secretion
- ELISA
- supernatant
- IL-1β secretion assay
- inflammatory diseases
- ulcerative colitis
- skin cancer
- Parkinson's disease
- Crohn's disease
- Alzheimer's disease
- Inhibitor
- inhibitor
- inhibit