Cat. No.: HY-N6679A

10,11-Dehydrocurvularin

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.

For research use only. We do not sell to patients.

Purity: 99.59%
CAS No.: 21178-57-4
Formula: C₁₆H₁₈O₅
Molecular Weight:290.31

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

10,11-Dehydrocurvularin Chemical Structure

CAS No.: 21178-57-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All HSP Isoforms :

All TGF-beta/Smad Isoforms :

Smad1
Smad3

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	4.3 μM Compound: 7	Cytotoxicity against human A2780 cells by MTT assay Cytotoxicity against human A2780 cells by MTT assay	[PMID: 39258410]
DU-145	IC₅₀	6 μM Compound: 5	Cytotoxic activity against human DU145 cells Cytotoxic activity against human DU145 cells	[PMID: 24195466]
HeLa	IC₅₀	6 μM Compound: 5	Cytotoxic activity against human HeLa cells Cytotoxic activity against human HeLa cells	[PMID: 24195466]
HeLa	IC₅₀	7.9 μM Compound: 7	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 39258410]
HepG2	IC₅₀	1.7 μM Compound: alpha,beta-Dehydrocurvularin	Binding affinity to (AGCCAGACA)9-MLP element (unknown origin) transiently transfected in human HepG2 cells assessed as inhibition of TGF-beta-induced Smad-dependent transcriptional activity preincubated for 1 hr before TGF-beta stimulation measured after Binding affinity to (AGCCAGACA)9-MLP element (unknown origin) transiently transfected in human HepG2 cells assessed as inhibition of TGF-beta-induced Smad-dependent transcriptional activity preincubated for 1 hr before TGF-beta stimulation measured after	[PMID: 25537529]
HepG2	IC₅₀	12 μM Compound: 7	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 39258410]
HepG2	IC₅₀	4.4 μM Compound: alpha,beta-Dehydrocurvularin	Inhibition of TGF-beta-induced human CTGF promoter activity transiently transfected in human HepG2 cells after 16 hrs by luciferase reporter assay Inhibition of TGF-beta-induced human CTGF promoter activity transiently transfected in human HepG2 cells after 16 hrs by luciferase reporter assay	[PMID: 25537529]
Huh-7	IC₅₀	5 μM Compound: 5	Cytotoxic activity against human HuH7 cells Cytotoxic activity against human HuH7 cells	[PMID: 24195466]
Jurkat	IC₅₀	5.5 μM Compound: 6	Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay	[PMID: 21146414]
K562	IC₅₀	37 μM Compound: 6	Cytotoxicity against human K562 cells after 24 hrs by MTT assay Cytotoxicity against human K562 cells after 24 hrs by MTT assay	[PMID: 21146414]
K562	IC₅₀	5.6 μM Compound: 6	Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay	[PMID: 21146414]
MCF7	IC₅₀	1.3 μM Compound: 4	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 15620238]
MCF7	IC₅₀	3.98 μM Compound: 3	Cytotoxicity against human MCF7 cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay Cytotoxicity against human MCF7 cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay	[PMID: 28139929]
MCF7	IC₅₀	4 μM Compound: 5	Cytotoxic activity against human MCF7 cells Cytotoxic activity against human MCF7 cells	[PMID: 24195466]
MDA-MB-231	IC₅₀	>5 μM Compound: 3	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay	[PMID: 28139929]
MIA PaCa-2	IC₅₀	1.9 μM Compound: 4	Cytotoxicity against human MIAPaCa2 cells by MTT assay Cytotoxicity against human MIAPaCa2 cells by MTT assay	[PMID: 15620238]
NCI-H460	IC₅₀	1.1 μM Compound: 4	Cytotoxicity against human NCI-H460 cells by MTT assay Cytotoxicity against human NCI-H460 cells by MTT assay	[PMID: 15620238]
NCI-H460	IC₅₀	3.57 μM Compound: 3	Cytotoxicity against human NCI-H460 cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay Cytotoxicity against human NCI-H460 cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay	[PMID: 28139929]
NCI-H460	IC₅₀	5 μM Compound: 5	Cytotoxic activity against human NCI-H460 cells Cytotoxic activity against human NCI-H460 cells	[PMID: 24195466]
PC-3M	IC₅₀	4.51 μM Compound: 3	Cytotoxicity against human PC3M cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay Cytotoxicity against human PC3M cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay	[PMID: 28139929]
SF-268	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human SF268 cells by MTT assay Cytotoxicity against human SF268 cells by MTT assay	[PMID: 15620238]
SF-268	IC₅₀	4.73 μM Compound: 3	Cytotoxicity against human SF268 cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay Cytotoxicity against human SF268 cells after 72 hrs by resazurin/AlamarBlue dye-based fluorescence assay	[PMID: 28139929]
SGC-7901	IC₅₀	6 μM Compound: 5	Cytotoxic activity against human SGC7901 cells Cytotoxic activity against human SGC7901 cells	[PMID: 24195466]
SK-OV-3	IC₅₀	20 μM Compound: 7	Cytotoxicity against human SK-OV-3 cells by MTT assay Cytotoxicity against human SK-OV-3 cells by MTT assay	[PMID: 39258410]
SW1990	IC₅₀	10 μM Compound: 5	Cytotoxic activity against human SW1990 cells Cytotoxic activity against human SW1990 cells	[PMID: 24195466]
U-937	IC₅₀	2.5 μM Compound: 6	Cytotoxicity against human U937 cells after 24 hrs by MTT assay Cytotoxicity against human U937 cells after 24 hrs by MTT assay	[PMID: 21146414]
WI-38	IC₅₀	3.6 μM Compound: 4	Cytotoxicity against human WI38 cells by MTT assay Cytotoxicity against human WI38 cells by MTT assay	[PMID: 15620238]

Chemical Information

CAS No. 21178-57-4
Appearance Solid
Molecular Weight 290.31
Formula C₁₆H₁₈O₅
Color White to light yellow
SMILES

OC1=C(C(/C=C/CCC[C@@H]2C)=O)C(CC(O2)=O)=CC(O)=C1
Structure Classification
- Phenols
- Polyphenols
- Antibiotics
- Macrolide Antibiotics
Initial Source
- Microorganisms
Aspergillus terreus
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

JACC Basic Transl Sci

ATP-Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance and Is Depressed in Human Failing Myocardium. [Abstract]

2025 Jun 10;10(7):101301. PMID: 40499285
FASEB J

Penicillide Triggers Immunogenic Pyroptosis in Tumor Cells via Oxidative Stress/NF-κB/GSDMD Signaling Axis. [Abstract]

2026 Mar 31;40(6):e71636. PMID: 41842655

Solvent & Solubility

In Vitro:

DMSO : ≥ 30 mg/mL (103.34 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4446 mL

17.2230 mL

34.4459 mL

5 mM

0.6889 mL

3.4446 mL

6.8892 mL

10 mM

0.3445 mL

1.7223 mL

3.4446 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47. [Content Brief]

[2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4446 mL	17.2230 mL	34.4459 mL	86.1148 mL
	5 mM	0.6889 mL	3.4446 mL	6.8892 mL	17.2230 mL
	10 mM	0.3445 mL	1.7223 mL	3.4446 mL	8.6115 mL
	15 mM	0.2296 mL	1.1482 mL	2.2964 mL	5.7410 mL
	20 mM	0.1722 mL	0.8611 mL	1.7223 mL	4.3057 mL
	25 mM	0.1378 mL	0.6889 mL	1.3778 mL	3.4446 mL
	30 mM	0.1148 mL	0.5741 mL	1.1482 mL	2.8705 mL
	40 mM	0.0861 mL	0.4306 mL	0.8611 mL	2.1529 mL
	50 mM	0.0689 mL	0.3445 mL	0.6889 mL	1.7223 mL
	60 mM	0.0574 mL	0.2870 mL	0.5741 mL	1.4352 mL
	80 mM	0.0431 mL	0.2153 mL	0.4306 mL	1.0764 mL
	100 mM	0.0344 mL	0.1722 mL	0.3445 mL	0.8611 mL

Keywords

10,11-Dehydrocurvularin

2 Cited Publications

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10,11-Dehydrocurvularin

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Publications Citing Use of MedChemExpress (MCE) 10,11-Dehydrocurvularin

All HSP Isoforms

All TGF-beta/Smad Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

10,11-Dehydrocurvularin Related Classifications

HY-N6679A Related Classifications