1. Stem Cell/Wnt
    TGF-beta/Smad
    PI3K/Akt/mTOR
  2. TGF-beta/Smad
    PI3K
  3. Disitertide

Disitertide (Synonyms: P144)

Cat. No.: HY-P0118
Handling Instructions

Disitertide (P144) is a peptidic TGFβ1 inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a PI3K inhibitor.

For research use only. We do not sell to patients.

Disitertide Chemical Structure

Disitertide Chemical Structure

CAS No. : 272105-42-7

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5 mg USD 528 Ask For Quote & Lead Time
10 mg USD 900 Ask For Quote & Lead Time
25 mg USD 1920 Ask For Quote & Lead Time

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Top Publications Citing Use of Products

    Disitertide purchased from MCE. Usage Cited in: Cell Death Differ. 2020 Jul 31.

    LINC00941-overexpressing cells treated with Disitertide (10 μM) shows increased mRNA and protein levels of ZO-1 and Ecadherin compared with controls. LINC00941-silenced cells show decreased mRNA and protein levels of ZO-1 and E-cadherin but increased mRNA and protein levels of Vimentin, Fibronectin, and Twist1.
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    Description

    Disitertide (P144) is a peptidic TGFβ1 inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a PI3K inhibitor[1][2].

    In Vitro

    Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells[2].
    Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance[3].

    Western Blot Analysis[2]

    Cell Line: Mouse embryo osteoblast precursor MC3T3-E1 cells.
    Concentration: 100 μg/mL.
    Incubation Time: 4 h.
    Result: Significantly suppressed the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.
    In Vivo

    Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment[4].

    Animal Model: Human hypertrophic scars were implanted in 60 nude mice[4].
    Dosage: 300 μg/mL was added the Lipogel.
    Administration: Topical application daily administered.
    Result: Successful shedding was achieved in 83,3% of the xenografts.
    Molecular Weight

    1580.82

    Formula

    C₆₈H₁₀₉N₁₇O₂₂S₂

    CAS No.

    272105-42-7

    Sequence Shortening

    TSLDASIIWAMMQN

    SMILES

    [TSLDASIIWAMMQN]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -80°C 2 years
      -20°C 1 year
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (63.26 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6326 mL 3.1629 mL 6.3258 mL
    5 mM 0.1265 mL 0.6326 mL 1.2652 mL
    10 mM 0.0633 mL 0.3163 mL 0.6326 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (1.58 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (1.58 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (1.58 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    DisitertideP144P 144P-144TGF-beta/SmadPI3KTransforming growth factor betaPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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