1. Stem Cell/Wnt
    TGF-beta/Smad
  2. TGF-beta/Smad
  3. Disitertide

Disitertide (Synonyms: P144)

Cat. No.: HY-P0118 Purity: 98.12%
Handling Instructions

Disitertide (P144) is an inhibitor of TGF-β1.

For research use only. We do not sell to patients.

Disitertide Chemical Structure

Disitertide Chemical Structure

CAS No. : 272105-42-7

Size Price Stock Quantity
1 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 528 In-stock
Estimated Time of Arrival: December 31
10 mg USD 900 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
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Customer Review

Based on 5 publication(s) in Google Scholar

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Description

Disitertide (P144) is an inhibitor of TGF-β1.

In Vitro

Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1].

In Vivo

Treatment with Disitertide (P144) at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].

Molecular Weight

1580.82

Formula

C₆₈H₁₀₉N₁₇O₂₂S₂

CAS No.

272105-42-7

Sequence

Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn

Sequence Shortening

TSLDASIIWAMMQN

SMILES

[TSLDASIIWAMMQN]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (63.26 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6326 mL 3.1629 mL 6.3258 mL
5 mM 0.1265 mL 0.6326 mL 1.2652 mL
10 mM 0.0633 mL 0.3163 mL 0.6326 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (1.58 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

DisitertideP144P 144P-144TGF-beta/SmadTransforming growth factor betaInhibitorinhibitorinhibit

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Disitertide
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