1. Stem Cell/Wnt
    TGF-beta/Smad
  2. TGF-beta/Smad

Disitertide (Synonyms: P144; P144 Peptide)

Cat. No.: HY-P0118 Purity: 98.12%
Handling Instructions

Disitertide also named P144, is a inhibitor of TGF-β1.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Disitertide Chemical Structure

Disitertide Chemical Structure

CAS No. : 272105-42-7

Size Price Stock Quantity
1 mg USD 132 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 528 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 900 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 1920 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Disitertide also named P144, is a inhibitor of TGF-β1. target: TGF-β1 [1] In vitro: prevented TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduced binding of TGF-β1 to its receptors. P144 blocked TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter. Intraperitoneal administration of P144 also showed potent antifibrogenic activity in vivo in the liver of rats receiving CCl4. [1] In vivo: Treatment with P144 at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide P144, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.[1]

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 0.6326 mL 3.1629 mL 6.3258 mL
5 mM 0.1265 mL 0.6326 mL 1.2652 mL
10 mM 0.0633 mL 0.3163 mL 0.6326 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

1580.82

Formula

C₆₈H₁₀₉N₁₇O₂₂S₂

CAS No.

272105-42-7

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 200 mg/mL; H2O: < 0.01 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Disitertide
Cat. No.:
HY-P0118
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