1. Stem Cell/Wnt
  2. TGF-beta/Smad
  3. Disitertide

Disitertide (Synonyms: P144)

Cat. No.: HY-P0118 Purity: 98.12%
Handling Instructions

Disitertide (P144) is an inhibitor of TGF-β1.

For research use only. We do not sell to patients.

Disitertide Chemical Structure

Disitertide Chemical Structure

CAS No. : 272105-42-7

Size Price Stock Quantity
1 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 528 In-stock
Estimated Time of Arrival: December 31
10 mg USD 900 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Disitertide (P144) is an inhibitor of TGF-β1.

In Vitro

Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1].

In Vivo

Treatment with Disitertide (P144) at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].

Molecular Weight








Sequence Shortening





Room temperature in continental US; may vary elsewhere.

Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (126.52 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6326 mL 3.1629 mL 6.3258 mL
5 mM 0.1265 mL 0.6326 mL 1.2652 mL
10 mM 0.0633 mL 0.3163 mL 0.6326 mL
*Please refer to the solubility information to select the appropriate solvent.
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The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


DisitertideP144P 144P-144TGF-beta/SmadTransforming growth factor betaInhibitorinhibitorinhibit

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