1. Immunology/Inflammation
  2. COX

Iguratimod (Synonyms: T614)

Cat. No.: HY-17009 Purity: 99.85%
Data Sheet SDS Handling Instructions

Iguratimod(T-614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor.

For research use only. We do not sell to patients.
Iguratimod Chemical Structure

Iguratimod Chemical Structure

CAS No. : 123663-49-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $110 In-stock
5 mg $100 In-stock
10 mg $150 In-stock
50 mg $650 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

Iguratimod(T-614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. IC50 value: Target: COX-2 Iguratimod(T 614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT03023592 Peking Union Medical College Hospital Sjogren's Syndrome February 2017 Phase 1|Phase 2
NCT01893151 Jiangsu Simcere Pharmaceutical Co., Ltd. Rheumatoid Arthritis July 2012 Phase 4
NCT01850966 Eisai Co., Ltd.|Eisai Inc. Rheumatoid Arthritis September 12, 2012
NCT03054545 RenJi Hospital Lupus Nephritis May 8, 2017
NCT01554917 Jiangsu Simcere Pharmaceutical Co., Ltd. Rheumatoid Arthritis May 2012 Phase 4
NCT01548001 Jiangsu Simcere Pharmaceutical Co., Ltd. Rheumatoid Arthritis May 2012 Phase 4
NCT02275299 Jiangsu Simcere Pharmaceutical Co., Ltd. Rheumatoid Arthritis September 2013 Phase 4
NCT02936375 RenJi Hospital Lupus Nephritis March 2017 Phase 2
NCT02839941 The First Affiliated Hospital with Nanjing Medical University Kidney Transplantation August 2016
NCT00965757 Eisai Co., Ltd.|Toyama Chemical Co., Ltd.|Eisai Inc. Rheumatoid Arthritis July 2009 Phase 3
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References
Molecular Weight

374.37

Formula

C₁₇H₁₄N₂O₆S

CAS No.

123663-49-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.85%

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Product Name:
Iguratimod
Cat. No.:
HY-17009
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