1. NF-κB
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  3. Ergolide

Ergolide 

Cat. No.: HY-N6893 Purity: 99.13%
Handling Instructions

Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB.

For research use only. We do not sell to patients.

Ergolide Chemical Structure

Ergolide Chemical Structure

CAS No. : 54999-07-4

Size Price Stock Quantity
5 mg USD 303 In-stock
Estimated Time of Arrival: December 31
10 mg USD 514 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Description

Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB[1].

IC50 & Target[1]

NF-κB

 

Molecular Weight

306.35

Formula

C₁₇H₂₂O₅

CAS No.

54999-07-4

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (163.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2642 mL 16.3212 mL 32.6424 mL
5 mM 0.6528 mL 3.2642 mL 6.5285 mL
10 mM 0.3264 mL 1.6321 mL 3.2642 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ErgolideNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Product Name:
Ergolide
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HY-N6893
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