2. Natural Products
  3. Plants
  4. Leguminosae
  5. Piptanthus nepalensis (Hook.) D. Don

Piptanthus nepalensis (Hook.) D. Don

Piptanthus nepalensis (Hook.) D. Don (9):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N6893
    Ergolide 54999-07-4 99.48%
    Ergolide is an orally active dual inhibitor targeting NF-κB/p65 and NLRP3. Ergolide blocks the NF-κB signaling pathway and the nuclear translocation of p65, and irreversibly binds to the NACHT domain of NLRP3 to inhibit inflammasome assembly. Ergolide significantly reduces the production of inflammatory mediators (e.g., NO, PGE2) and cytokines, induces cancer cell apoptosis, autophagy and ROS generation. Ergolide also enhances the anti-tumor effect of vincristine. Ergolide alleviates acute lung injury via an NLRP3-dependent mechanism, and effectively improves the survival rate and behavioral function of septic mice and inflammatory zebrafish models. Ergolide is used in the research of metastatic uveal melanoma, neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease), sepsis and acute lymphoblastic leukemia.
    Ergolide
  • HY-N8831
    Daidzein-4',7-diglucoside 53681-67-7 99.74%
    Daidzein-4',7-diglucoside is a natural product that can be isolated from Radix puerariae.
    Daidzein-4',7-diglucoside
  • HY-N12589
    8-epi-Helenalin 97643-91-9
    8-epi-Helenalin is a semitterpene lactone with anti-tumor activity that can be isolated from Inula britannicaL. var. chinensis (Rupr.) Reg. and the ED50 values of 8-epi-Helenalin for HL-60, A549, MCF7, HCT-15, SK-OV-3 and Malme-3M are 12.2 μM, 53.8 μM, 9.1 μM, 8.7 μM, 18.7 μM and 8.3 μM, respectively. 8-epi-Helenalin can be used for anti-tumor studies.
    8-epi-Helenalin
  • HY-N8940
    1-O-Acetyl-6-O-isobutyrylbritannilactone 1613152-34-3
    1-O-Acetyl-6-O-isobutyrylbritannilactone is a Sesquiterpenoids product that can be isolated from the flower heads of Inula britannica..
    1-O-Acetyl-6-O-isobutyrylbritannilactone
  • HY-N8946
    1-O-Acetyl-6alpha-O-(2-methylbutyryl)britannilactone 1932687-71-2
    1-O-Acetyl-6alpha-O-(2-methylbutyryl)britannilactone is a Sesquiterpenoids product that can be isolated from the flower heads of Inula britannica..
    1-O-Acetyl-6alpha-O-(2-methylbutyryl)britannilactone
  • HY-N7337
    Dibritannilactone B 1829580-18-8
    Dibritannilactone B is a Sesquiterpenoids product that can be isolated from the aerial parts of Inula britannica..
    Dibritannilactone B
  • HY-N2850
    α-Spinasterol acetate 4651-46-1
    α-Spinasterol acetate (5α-Stigmasta-7,22-dien-3β-ol, acetate) is a Sesquiterpenoids product that can be isolated from the roots of Trigonostemon chinensis Merr..
    α-Spinasterol acetate
  • HY-N4190
    Britannilactone diacetate 1286694-67-4
    Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property.
    Britannilactone diacetate
  • HY-123091
    Ivangustin 14164-59-1 99.48%
    Ivangustin is a sesquiterpene isolated from the flower heads of the medicinal plant Inula britannica.
    Ivangustin