Britannilactone diacetate
Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property.
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- CAS No.: 1286694-67-4
- Formule: C19H26O6
- Masse moléculaire:350.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | EC50 |
6.3 μM
Compound: 2; OABL
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Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay
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[PMID: 34315042] |
| HCT-116 | IC50 |
10.1 μM
Compound: OABL
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
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10.1039/C4MD00209A |
| HeLa | IC50 |
11.2 μM
Compound: OABL
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
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10.1039/C4MD00209A |
| SGC-7901 | IC50 |
15.9 μM
Compound: OABL
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Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
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10.1039/C4MD00209A |
Chemical Information
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CAS No. 1286694-67-4
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Masse moléculaire 350.41
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Formule C19H26O6
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SMILES
O=C1O[C@@]2([H])[C@@]([C@H](OC(C)=O)C([C@@H](C)CCCOC(C)=O)=C(C)C2)([H])C1=C
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Synonyms
1,6-O,O-Diacetylbritannilactone; Di-O-acetylbritannilactone
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Britannilactone diacetate Related Classifications
HY-N4190 Related Classifications
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