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Cat. No.: HY-184844

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NLRP3 modulator 8

NLRP3 modulator 8 (compound 248) is a NLRP3 inhibitor. NLRP3 modulator 8 inhibits LPS (HY-D1056)-induced IL-1β secretion in PMA-differentiated THP-1 cells with an IC₅₀ of 3 nM. NLRP3 modulator 8 can be used in studies related to NLRP3 inflammasome activation and innate immune signaling.

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CAS No.: 2771020-68-7
Formule: C₁₈H₂₀FIN₂O₃
Masse moléculaire:458.27

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NLRP3 modulator 8 Chemical Structure

CAS No.: 2771020-68-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

NLRP3

3 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform NOD-like Receptor (NLR) :

Voir tous les produits spécifiques à Isoform Interleukin Related :

In Vitro

Innate Immunity

NLRP3 modulator 8 (compound 248) (induced with PMA (HY-18739) at 5 ng/mL for 40 h; stimulated with LPS at 25 ng/mL for 2 h; treated for 1 h; stimulated with Nigericin (HY-127019) at 5 μM for 2 h) inhibits IL-1β secretion in THP-1 cells with an IC₅₀ of 3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 2771020-68-7
Masse moléculaire 458.27
Formule C₁₈H₂₀FIN₂O₃
SMILES

F[C@@H]1[C@]2(C1)C3=CC(I)=CC=C3C(N(C2)CC(N[C@H]4C[C@@](O)(C4)C)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Bagdasarian AL, et al. Compounds, compositions, and methods. WO 2022/232632 A1. World Intellectual Property Organization. 2022-11-03.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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