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Cat. No.: HY-184844

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NLRP3 modulator 8-1

NLRP3 modulator 8 (compound 248) is a NLRP3 inhibitor. NLRP3 modulator 8 inhibits LPS (HY-D1056)-induced IL-1β secretion in PMA-differentiated THP-1 cells with an IC₅₀ of 3 nM. NLRP3 modulator 8 can be used in studies related to NLRP3 inflammasome activation and innate immune signaling . .

For research use only. We do not sell to patients.

CAS No.: 2771020-68-7
Formula: C₁₈H₂₀FIN₂O₃
Molecular Weight:458.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NLRP3 modulator 8-1 Chemical Structure

CAS No.: 2771020-68-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target^[1]

NLRP3

3 nM (IC₅₀)

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

In Vitro

NLRP3 modulator 8 (compound 248) (induced with PMA (HY-18739) at 5 ng/mL for 40 h; stimulated with LPS at 25 ng/mL for 2 h; treated for 1 h; stimulated with Nigericin (HY-127019) at 5 μM for 2 h) inhibits IL-1β secretion in THP-1 cells with an IC₅₀ of 3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2771020-68-7
Molecular Weight 458.27
Formula C₁₈H₂₀FIN₂O₃
SMILES

F[C@@H]1[C@]2(C1)C3=CC(I)=CC=C3C(N(C2)CC(N[C@H]4C[C@@](O)(C4)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bagdasarian AL, et al. Compounds, compositions, and methods. WO 2022/232632 A1. World Intellectual Property Organization. 2022-11-03.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NLRP3 modulator 8-1

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NLRP3 modulator 8-1 Related Classifications

HY-184844 Related Classifications