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Art. -Nr.: HY-184844

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NLRP3 modulator 8

NLRP3 modulator 8 (compound 248) is a NLRP3 inhibitor. NLRP3 modulator 8 inhibits LPS (HY-D1056)-induced IL-1β secretion in PMA-differentiated THP-1 cells with an IC₅₀ of 3 nM. NLRP3 modulator 8 can be used in studies related to NLRP3 inflammasome activation and innate immune signaling.

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CAS. Nr.: 2771020-68-7
Formel: C₁₈H₂₀FIN₂O₃
Molecular Weight:458.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NLRP3 modulator 8 Chemical Structure

CAS. Nr.: 2771020-68-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

NLRP3

3 nM (IC₅₀)

Alle NOD-like Receptor (NLR) Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

NLRP3 modulator 8 (compound 248) (induced with PMA (HY-18739) at 5 ng/mL for 40 h; stimulated with LPS at 25 ng/mL for 2 h; treated for 1 h; stimulated with Nigericin (HY-127019) at 5 μM for 2 h) inhibits IL-1β secretion in THP-1 cells with an IC₅₀ of 3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2771020-68-7
Molecular Weight 458.27
Formel C₁₈H₂₀FIN₂O₃
SMILES

F[C@@H]1[C@]2(C1)C3=CC(I)=CC=C3C(N(C2)CC(N[C@H]4C[C@@](O)(C4)C)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bagdasarian AL, et al. Compounds, compositions, and methods. WO 2022/232632 A1. World Intellectual Property Organization. 2022-11-03.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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