2771020-68-7
2771020-68-7
Chemical Structure
NLRP3 modulator 8
- CAS No.: 2771020-68-7
- Formula:C18H20FIN2O3
- Molecular Weight:458.27
InChIKey: ISCGORQXDUHUAG-PQSSYKNCSA-N
SMILES: F[C@@H]1[C@]2(C1)C3=CC(I)=CC=C3C(N(C2)CC(N[C@H]4C[C@@](O)(C4)C)=O)=O
Biological Activity: NLRP3 modulator 8 (compound 248) is a NLRP3 inhibitor. NLRP3 modulator 8 inhibits LPS (HY-D1056)-induced IL-1β secretion in PMA-differentiated THP-1 cells with an IC50 of 3 nM. NLRP3 modulator 8 can be used in studies related to NLRP3 inflammasome activation and innate immune signaling[1].
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NLRP3 modulator 8 | NLRP3 modulator 8 (compound 248) is a NLRP3 inhibitor. NLRP3 modulator 8 inhibits LPS (HY-D1056)-induced IL-1β secretion in PMA-differentiated THP-1 cells with an IC50 of 3 nM. NLRP3 modulator 8 can be used in studies related to NLRP3 inflammasome activation and innate immune signaling. | |||||||||||||||||||||
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