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Cat. No.: HY-144220

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NLRP3/AIM2-IN-1

NLRP3/AIM2-IN-1 is a thermal sepsis inhibitor with an IC 50 value of 3.136 ± 0.7667 μ M.

For research use only. We do not sell to patients.

CAS No.: 3033386-91-0
Formula: C₁₅H₁₆BNO₄
Molecular Weight:285.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NLRP3/AIM2-IN-1 Chemical Structure

CAS No.: 3033386-91-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

NLRP3/AIM2-IN-1 is a thermal sepsis inhibitor with an IC 50 value of 3.136 ± 0.7667 μ M.

IC₅₀ & Target

inhibitory activity against NLRP3 and AIM2

3.136±0.76 μM (IC₅₀)

All NOD-like Receptor (NLR) Isoforms :

Chemical Information

CAS No. 3033386-91-0
Molecular Weight 285.10
Formula C₁₅H₁₆BNO₄
SMILES

COC1=CC=C(C=C1)CC(NC2=CC=CC(B(O)O)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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NLRP3/AIM2-IN-1

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NLRP3/AIM2-IN-1 Related Classifications

HY-144220 Related Classifications