NLRP3/AIM2-IN-1
NLRP3/AIM2-IN-1 is an NLRP3/AIM2 inhibitor with an IC50 of 3.136 μM against NLRP3-dependent pyroptosis. NLRP3/AIM2-IN-1 inhibits IL-1β secretion triggered by NLRP3 inflammasome activation. NLRP3/AIM2-IN-1 exhibits moderate anti-pyroptotic activity. NLRP3/AIM2-IN-1 does not inhibit NLRC4 inflammasome activation. NLRP3/AIM2-IN-1 can be used for studying inflammasome-mediated inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 3033386-91-0
- Formula: C15H16BNO4
- Molecular Weight:285.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
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NLRP3 3.136 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| THP-1 | IC50 |
3.136 μM
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Inhibition of nigericin-induced NLRP3-dependent pyroptosis in PMA-differentiated human THP-1 macrophages assessed as improvement of cell viability via MTT assay, following 4 h LPS priming, 30 min pre-incubation with NLRP3/AIM2-IN-1, and 3 h nigericin stimulation.
Inhibition of nigericin-induced NLRP3-dependent pyroptosis in PMA-differentiated human THP-1 macrophages assessed as improvement of cell viability via MTT assay, following 4 h LPS priming, 30 min pre-incubation with NLRP3/AIM2-IN-1, and 3 h nigericin stimulation.
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35183871 |
NLRP3/AIM2-IN-1 (compound 1) (0.4-100 μM; 30 min pre-incubation before 3 h nigericin stimulation) moderately inhibits Nigericin (HY-127019)-induced NLRP3-dependent pyroptosis in human THP-1 macrophages with an IC50 of 3.136 μM[1].
NLRP3/AIM2-IN-1 (0.4-100 μM; 30 min pre-incubation before 30 min nigericin stimulation) dose-dependently inhibits NLRP3-dependent IL-1β secretion in human THP-1 macrophages, but does not achieve full inhibition even at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PMA-differentiated human THP-1 macrophages
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Concentration:0.4-100 μM
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Incubation Time:30 min
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Result:Exhibited moderate dose-dependent improvement of cell viability in Nigericin-induced pyroptosis.
Reached a half-maximal inhibitory concentration (IC50) of 3.136 μM for pyroptosis inhibition.
Failed to completely protect cells from pyroptosis even at the highest tested concentration of 100 μM.
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Cell Line:PMA-differentiated human THP-1 macrophages
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Concentration:0.4-100 μM
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Incubation Time:30 min
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Result:Showed dose-dependent inhibition of IL-1β secretion triggered by LPS and Nigericin.
Failed to completely block IL-1β release even at 100 μM.
Chemical Information
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CAS No. 3033386-91-0
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Molecular Weight 285.10
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Formula C15H16BNO4
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SMILES
COC1=CC=C(C=C1)CC(NC2=CC=CC(B(O)O)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3/AIM2-IN-1 Related Classifications
HY-144220 Related Classifications
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