3033386-91-0
Chemical Structure
NLRP3/AIM2-IN-1
- CAS No.: 3033386-91-0
- Formula:C15H16BNO4
- Molecular Weight:285.10
IUPAC Name: 2-hydroxy-2,2-bis(thiophen-2-yl-d3)acetic acid
InChIKey: MLFLVONTTDCYQV-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)CC(NC2=CC=CC(B(O)O)=C2)=O
Biological Activity: NLRP3/AIM2-IN-1 is an NLRP3/AIM2 inhibitor with an IC50 of 3.136 μM against NLRP3-dependent pyroptosis. NLRP3/AIM2-IN-1 inhibits IL-1β secretion triggered by NLRP3 inflammasome activation. NLRP3/AIM2-IN-1 exhibits moderate anti-pyroptotic activity. NLRP3/AIM2-IN-1 does not inhibit NLRC4 inflammasome activation. NLRP3/AIM2-IN-1 can be used for studying inflammasome-mediated inflammatory diseases[1].
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NLRP3/AIM2-IN-1 | NLRP3/AIM2-IN-1 is an NLRP3/AIM2 inhibitor with an IC50 of 3.136 μM against NLRP3-dependent pyroptosis. NLRP3/AIM2-IN-1 inhibits IL-1β secretion triggered by NLRP3 inflammasome activation. NLRP3/AIM2-IN-1 exhibits moderate anti-pyroptotic activity. NLRP3/AIM2-IN-1 does not inhibit NLRC4 inflammasome activation. NLRP3/AIM2-IN-1 can be used for studying inflammasome-mediated inflammatory diseases. | |||||||||||||||||||||
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Keywords
