MR2938
MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research.
For research use only. We do not sell to patients.
- CAS No.: 1044870-65-6
- Formula: C21H24N4O3
- Molecular Weight:380.44
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
AChE 5.04 ± 0.7 μM (IC50) |
BChE >20 μM (IC50) |
NF-κB |
IL-1β |
IL-6 |
NLRP3 |
JNK |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
3.29 μM
Compound: B12; MR2938
|
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 24 hrs followed by LPS stimulation by Griess reagent-based colorimetric assay
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 24 hrs followed by LPS stimulation by Griess reagent-based colorimetric assay
|
[PMID: 37043994] |
MR2938 (0-10 μM, 24 h) decreases the mRNA levels of pro-inflammatory cytokines IL-1β, TNF-α, IL-6 and CCL2 at 1.25 μM[1].
MR2938 (10 μM, 24 h) blocks NF-κB signaling pathway in LPS-induced BV-2 cells[1].
MR2938 (20 μM) shows inhibitory activities against AChE and BChE, with inhibitory rates of 91.8 ± 2.68% and 38.7 ± 11.7%, respectively[1].
MR2938 (0-10 μM) has little effect on cell viability on BV2 cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:BV-2 cells
-
Concentration:0, 1.25, 2.5, 5, and 10 μM
-
Incubation Time:24 h
-
Result:Dramatically and dose dependently reduced the mRNA levels of inflammatory factors stimulated by LPS (1 μg/mL). Compared with TNF-α, the inhibitory effect of MR2938 on IL-1β, IL-6 and CCL2 was much potent.
-
Cell Line:BV-2 cells
-
Concentration:10 μM
-
Incubation Time:24 h
-
Result:Suppressed the expression level of p65 protein, and reduced the p-p65 level. Reduced NLRP3 expression obviously. Reduced the phosphorylation level of JNK induced by LPS stimulation, while the level of JNK protein was hardly changed.
Chemical Information
-
CAS No. 1044870-65-6
-
Molecular Weight 380.44
-
Formula C21H24N4O3
-
SMILES
COC1=CC(OC)=C2C(NC(C3=CC=C(C=C3)N4CCN(CC4)C)=NC2=C1)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz