Search Result

Results for "

Acetylcholinesterase

" in MCE Product Catalog:

By Targets:	5-HT Receptor (2) Aldehyde Dehydrogenase (ALDH) (1) Amyloid-β (4) Apoptosis (7) Bacterial (4) Beta-secretase (2) Bradykinin Receptor (1) Carbonic Anhydrase (2) Cholinesterase (ChE) (125) COX (1) Dopamine Receptor (1) Endogenous Metabolite (4) Endothelin Receptor (1) Epoxide Hydrolase (2) Fungal (2) G-quadruplex (1) Glucosidase (2) GPR55 (1) GSK-3 (1) HBV (1) Histamine Receptor (2) iGluR (1) Interleukin Related (1) Keap1-Nrf2 (2) Kisspeptin Receptor (3) mAChR (1) Microtubule/Tubulin (1) MMP (1) Monoamine Oxidase (9) nAChR (1) NO Synthase (2) P-glycoprotein (3) Parasite (4) PD-1/PD-L1 (2) Phosphatase (2) PPAR (1) ROS Kinase (4) SARS-CoV (1) Somatostatin Receptor (2) Telomerase (1) Topoisomerase (1) Vasopressin Receptor (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (4) Endocrinology (3) Infection (13) Inflammation/Immunology (21) Metabolic Disease (13) Neurological Disease (93)

By Targets:

5-HT Receptor (2)

Aldehyde Dehydrogenase (ALDH) (1)

Amyloid-β (4)

Apoptosis (7)

Bacterial (4)

Beta-secretase (2)

Bradykinin Receptor (1)

Carbonic Anhydrase (2)

Cholinesterase (ChE) (125)

COX (1)

Dopamine Receptor (1)

Endogenous Metabolite (4)

Endothelin Receptor (1)

Epoxide Hydrolase (2)

Fungal (2)

G-quadruplex (1)

Glucosidase (2)

GPR55 (1)

GSK-3 (1)

HBV (1)

Histamine Receptor (2)

iGluR (1)

Interleukin Related (1)

Keap1-Nrf2 (2)

Kisspeptin Receptor (3)

mAChR (1)

Microtubule/Tubulin (1)

MMP (1)

Monoamine Oxidase (9)

nAChR (1)

NO Synthase (2)

P-glycoprotein (3)

Parasite (4)

PD-1/PD-L1 (2)

Phosphatase (2)

PPAR (1)

ROS Kinase (4)

SARS-CoV (1)

Somatostatin Receptor (2)

Telomerase (1)

Topoisomerase (1)

Vasopressin Receptor (1)

By Research Areas:

Cancer (27)

Cardiovascular Disease (4)

Endocrinology (3)

Infection (13)

Inflammation/Immunology (21)

Metabolic Disease (13)

Neurological Disease (93)

145

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-P2860

*Acetylcholinesterase* ACHE; EC 3.1.1.7	Cholinesterase (ChE)	Neurological Disease
Acetylcholinesterase (ACHE; EC 3.1.1.7) is a cholinergic enzyme mainly found in neuromuscular junctions and cholinergic type chemical synapses, and is often used in biochemical research. Acetylcholinesterase catalyzes the breakdown or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetate and choline. Acetylcholinesterase's main role is to terminate neuronal transmission and signaling between synapses to prevent ACh spread and activation of nearby receptors.

HY-W077226

AChE-IN-23
Cholinesterase (ChE) Neurological Disease

AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 48.3 μM.

AChE-IN-23	Cholinesterase (ChE)	Neurological Disease
AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 48.3 μM.

HY-N1089

Vincosamide	Cholinesterase (ChE)	Inflammation/Immunology
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the *acetylcholinesterase* (AChE) activity with anti-inflammatory activity.

HY-N10209

Paecilomide
Cholinesterase (ChE) Others

Paecilomide is a pyridone alkaloid and acetylcholinesterase inhibitor.

Paecilomide	Cholinesterase (ChE)	Others
Paecilomide is a pyridone alkaloid and *acetylcholinesterase* inhibitor.

HY-75247

Coumaran 2,3-Dihydrobenzofuran	Cholinesterase (ChE) Endogenous Metabolite	Neurological Disease
Coumaran (2,3-Dihydrobenzofuran) is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide.

HY-N0528

Linarin Buddleoside; Linarine	Cholinesterase (ChE)	Neurological Disease
Linarin (Buddleoside), isolated from the flower extract of Mentha arvensis, shows selective dose dependent inhibitory effect on acetylcholinesterase (AChE).

HY-N6575

7β-Hydroxybufalin	Glucosidase Cholinesterase (ChE)	Metabolic Disease
7β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and *acetylcholinesterase*.

HY-124140

Heliosupine	Cholinesterase (ChE)	Others
Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores.

HY-B1093

Fenchlorphos	Parasite Cholinesterase (ChE)	Infection
Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction.

HY-N7480A

Quinolactacin A1	Cholinesterase (ChE)	Neurological Disease
Quinolactacin A1 is a potent *acetylcholinesterase* (AChE) inhibitor from solid state fermentation of Penicillium citrinum 90648. Quinolactacin A1 can be used for the research of Alzheimer disease.

HY-N6619A

Lycoramine	Cholinesterase (ChE)	Neurological Disease
Lycoramine, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor.

HY-N6619

Lycoramine hydrobromide	Cholinesterase (ChE)	Neurological Disease
Lycoramine hydrobromide, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine hydrobromide is a potent acetylcholinesterase (AChE) inhibitor.

HY-144762

K027	Cholinesterase (ChE)	Neurological Disease
K027 is a potent reactivator of Organophosphates (OP)-inhibited acetylcholinesterase (AChE). K027 can be used for the research of Alzheimer's disease.

HY-W011108

Obidoxime dichloride	Cholinesterase (ChE)	Neurological Disease
Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated.

HY-N6310

Talaromycesone A	Bacterial	Infection
Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC₅₀ of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC₅₀ of 7.49 μM.

HY-146035

AChE-IN-14	Cholinesterase (ChE) Histamine Receptor	Neurological Disease
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC₅₀s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H₃ receptor (H₃R; K_i= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease.

HY-N2511

Trimyristin	Cholinesterase (ChE) Phosphatase Endogenous Metabolite	Metabolic Disease
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits *acetylcholinesterase* (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively.

HY-122957

Huperzine C	Cholinesterase (ChE)	Neurological Disease
Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC₅₀ of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease.

HY-131971

AChE/BChE-IN-1	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-1 is a potent and brain-penetrant dual inhibitor of *Acetylcholinesterase* and Butyrylcholinesterase, with IC₅₀s of 1.06 and 7.3 nM for hAChE and hBChE, respectively. AChE/BChE-IN-1 also has antioxidant activity. AChE/BChE-IN-1 can be used for the research of Alzheimer’s disease.

HY-150728

AChE-IN-22	Cholinesterase (ChE)	Neurological Disease
AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against AChE and BuChE with the IC₅₀ values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer's disease.

HY-124047

RX 67668	Cholinesterase (ChE)	Neurological Disease
RX 67668 is a potent *cholinesterase* inhibitor with an IC₅₀ of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue.

HY-150003

Aβ1–42 aggregation inhibitor 1	Cholinesterase (ChE) Amyloid-β	Neurological Disease
Aβ1-42 aggregation inhibitor 1 inhibits AChE (acetylcholinesterase) and BuChE (butyrylcholinesterase) with the IC₅₀ value of 2.64 μM and 1.29 μM, respectively. Aβ1-42 aggregation inhibitor 1 inhibits self-mediated Aβ1-42 aggregation by 51.29% at a concentration of 25 μM. Aβ1-42 aggregation inhibitor 1 has the potential for the research of anti-Alzheimer's disease.

HY-144660

AChE-IN-7	Cholinesterase (ChE)	Neurological Disease
AChE-IN-7 (Compound 16) is a selective and potent inhibitor of *acetylcholinesterase* (eeAChE IC₅₀ = 0.045 μM; eeBuChE IC₅₀ = 19.68 μM). AChE-IN-7 is safe in vivo and in vitro, and shows good overall pharmacokinetic performance and high bioavailability (F = 55.5%). AChE-IN-7 also has high BBB permeability.

HY-146039

AChE-IN-15	Cholinesterase (ChE)	Neurological Disease
AChE-IN-15 (Compound 3d) is a reversible human acetylcholinesterase (huAChE) (IC₅₀=6.8 μM) and human butyrylcholinesterase (huBChE) (IC₅₀=16.1 μM) inhibitor. AChE-IN-15 shows significant antioxidant potency, AChE-IN-15 can be used for the research of Alzheimer’s disease.

HY-N8161

Kaempferol-3,7-di-O-β-glucoside Kaempferol 3,7-diglucoside	Glucosidase Cholinesterase (ChE)	Neurological Disease
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, α-glucosidase and *Acetylcholinesterase*. Kaempferol-3,7-di-O-β-glucoside protects differentiating neuronal cells, SH-SY5Y from Amyloid β peptide-induced injury. Kaempferol-3,7-di-O-β-glucoside has the potential for Alzheimer's research.

HY-14833

Atiratecan TP300	Topoisomerase	Cancer
Atiratecan (TP300) is a prodrug of camptothecin analog CH0793076 (HY-107096). Atiratecan does not inhibit acetylcholinesterase (AChE) activities. Atiratecan shows antitumor activity against both breast cancer resistance protein (BCRP)-positive and -negative xenografts in mouse xenograft models.

HY-P1016A

BQ-3020 TFA	Endothelin Receptor	Cardiovascular Disease Endocrinology
BQ-3020 (TFA) is a selective agonist of ET_B receptor, inhibits [¹²⁵I]ET-1 binding to ET_B receptor with an IC₅₀ of 0.2 nM in cerebellum, and causes vasoconstriction.

HY-N5077

Sinapine	Cholinesterase (ChE) P-glycoprotein	Cancer Inflammation/Immunology Neurological Disease
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

HY-N5077B

Sinapine hydroxide	Cholinesterase (ChE) P-glycoprotein	Cancer Inflammation/Immunology Neurological Disease
Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

HY-N0450

Sinapine thiocyanate	P-glycoprotein Cholinesterase (ChE)	Cancer
Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

HY-B0882

Edrophonium chloride	Cholinesterase (ChE)	Neurological Disease
Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.

HY-P2161B

TAK-683 acetate	Kisspeptin Receptor	Cancer
TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P2161A

TAK-683 TFA	Kisspeptin Receptor	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P2161

TAK-683	Kisspeptin Receptor	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-N0342

Scopoletin
Gelseminic acid; Chrysatropic acid
Cholinesterase (ChE) Apoptosis Inflammation/Immunology

Scopoletin is an inhibitor of acetylcholinesterase (AChE).
HY-N10060

Millmerranone A
Cholinesterase (ChE) Neurological Disease

Millmerranone A shows the acetylcholinesterase inhibitory property.

Scopoletin Gelseminic acid; Chrysatropic acid	Cholinesterase (ChE) Apoptosis	Inflammation/Immunology
Scopoletin is an inhibitor of acetylcholinesterase (AChE).

Millmerranone A	Cholinesterase (ChE)	Neurological Disease
Millmerranone A shows the *acetylcholinesterase* inhibitory property.

HY-B0882S

Edrophonium-d5 chloride	Cholinesterase (ChE)	Neurological Disease
Edrophonium-d₅ (chloride) is the deuterium labeled Edrophonium chloride. Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.

HY-76299

Galanthamine
Galantamine
Cholinesterase (ChE) Apoptosis Neurological Disease

Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

Galanthamine Galantamine	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-P3061

[Hyp3]-Bradykinin	Bradykinin Receptor	Endocrinology Cardiovascular Disease
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts.

HY-B0884

Minaprine
Monoamine Oxidase Neurological Disease

Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

Minaprine	Monoamine Oxidase	Neurological Disease
Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

HY-B0884A

Minaprine dihydrochloride	Monoamine Oxidase	Neurological Disease
Minaprine dihydrochloride is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

HY-114899

Azamethiphos
Cholinesterase (ChE) Parasite Neurological Disease

Azamethiphos is an organophosphate insecticide and a neurotoxic agent, causing acetylcholinesterase (AChE) inhibition.

Azamethiphos	Cholinesterase (ChE) Parasite	Neurological Disease
Azamethiphos is an organophosphate insecticide and a neurotoxic agent, causing acetylcholinesterase (AChE) inhibition.

HY-B1206

Neostigmine methyl sulfate	Cholinesterase (ChE)	Neurological Disease
Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier.

HY-N0810

Timosaponin AIII
Cholinesterase (ChE) Neurological Disease Cancer

Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC₅₀ of 35.4 μM.

Timosaponin AIII	Cholinesterase (ChE)	Neurological Disease Cancer
Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC₅₀ of 35.4 μM.

HY-152037

AChE/Nrf2 modulator 1	Cholinesterase (ChE) Keap1-Nrf2	Neurological Disease
AChE/Nrf2 modulator 1 is an orally active acetylcholinesterase (AChE)/nuclear factor erythroid 2-related factor 2 (Nrf2) modulator. AChE/Nrf2 modulator 1 has Nrf2 inductive activity and AChE inhibitory activity for eeAChE and hAChE with IC₅₀ values of 0.07 μM and 0.38 μM, respectively. AChE/Nrf2 modulator 1 can be used for the research of Alzheimer's disease.

HY-113626

(-)-Cyclopenin (-)-Cyclopenine	Cholinesterase (ChE)	Metabolic Disease
(-)-Cyclopenin ((-)-Cyclopenine) is the enantiomer of Cyclopenin. Cyclopenin is a selective *acetylcholinesterase* (AChE) inhibitor with the IC₅₀ of 2.04 μM.

HY-N4261

Dehydronuciferine	Cholinesterase (ChE)	Metabolic Disease
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 25 μg/mL.

HY-B0832

Profenofos	Cholinesterase (ChE)	Neurological Disease
Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity.

HY-N7612

N-Desmethyl Galanthamine N-Norgalanthamine	Cholinesterase (ChE)	Others
N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-W004287

Methyl tridecanoate	Amyloid-β Cholinesterase (ChE)	Neurological Disease
Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).

HY-N2176A

(±)-Marmesin	Cholinesterase (ChE)	Others
(±)-Marmesin is a good precursor of the linear furanocoumarins. (±)-Marmesin derivatives have high degree of *acetylcholinesterase* inhibitory property.

HY-U00028

T 82
5-HT Receptor Cholinesterase (ChE) Neurological Disease

T 82 is a potent 5-HT3 antagonist and acetylcholinesterase (AChE) inhibitor, used for treatment of Alzheimer's Disease.

HY-76299S1

Galanthamine-O-methyl-d3	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine-O-methyl-d₃ is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

HY-N0286

Isoimperatorin	Cholinesterase (ChE) Bacterial	Neurological Disease Cancer
Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC₅₀ of 74.6 μM.

HY-151927

AChE-IN-28
Cholinesterase (ChE) Neurological Disease

AChE-IN-28 (Compound 2h) is a selective slow-binding inhibitor of acetylcholinesterase with an IC₅₀ of 0.2 nM.

HY-P2798

*Cholinesterase* EC 3.1.1.8; BCHE	Endogenous Metabolite	Others
Cholinesterase infers to acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). AChE and BChE catalyze the hydrolysis of 6-MAM to morphine.

HY-N5120

Dihydrowithaferin A 2,3-Dihydrowithaferin A	Cholinesterase (ChE)	Cancer
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE).

HY-N9513

Echimidine N-oxide
Cholinesterase (ChE) Neurological Disease

Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC_{50=0.347 mM).}

HY-110389

Pitofenone hydrochloride	Cholinesterase (ChE)	Neurological Disease
Pitofenone hydrochloride, a spasmolytic compound, inhibits the *acetylcholinesterase* (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively.

HY-131413

O-Desmethyl Galanthamine Sanguinine	Cholinesterase (ChE)	Neurological Disease
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 1.83 μM.

HY-N0825

Nodakenin	Cholinesterase (ChE)	Inflammation/Immunology
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM.

HY-N2192

Swertianolin	Cholinesterase (ChE) HBV Bacterial	Infection Inflammation/Immunology
Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin also exhibits anti-HBV and anti-bacterial activity.

HY-126765

Territrem B	Cholinesterase (ChE)	Infection Neurological Disease
Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus.

HY-144392

AChE/BuChE-IN-1	Cholinesterase (ChE)	Neurological Disease
AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC₅₀ of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC₅₀ of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC₅₀ of 0.1674 μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ_1-42 aggregation (self-, Cu₂₊-induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has the potential for Alzheimer' disease (AD) research.

HY-N6895

Violanthin	Cholinesterase (ChE)	Inflammation/Immunology
Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC₅₀ value of 79.80 μM.

HY-76299S

Galanthamine-d6	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine-d₆ (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

HY-N0826

Corynoline	Cholinesterase (ChE) Keap1-Nrf2	Inflammation/Immunology Neurological Disease Cancer
Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM. Corynoline exhibits anti-inflammatory activity by activating Nrf2.

HY-147880

BChE-IN-9
Cholinesterase (ChE) Neurological Disease

BChE-IN-9 (Azepano-11-deoxo-glycyrrhetol) is a mixed type BChE inhibitor with a K_i of 0.21 µM.

HY-W016188

1-Naphthyl acetate	Cholinesterase (ChE)	Others
1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. 1-Naphthyl acetate has the potential to detect organophosphorus pesticide (OP) poisoning.

HY-151370

AChE-IN-26	Cholinesterase (ChE)	Neurological Disease
AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor with an IC₅₀ value of 0.42 μM. AChE-IN-26 can be used for the research of Alzheimer’s disease.

HY-17388

(±)-Huperzine A	Cholinesterase (ChE)	Neurological Disease
(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).

HY-W017423

(-)-Carvone	Cholinesterase (ChE)	Neurological Disease
(-)-Carvone is an insect neurotoxin and a irreversible *acetylcholinesterase* (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae.

HY-151338

AChE-IN-25	Cholinesterase (ChE)	Neurological Disease
AChE-IN-25 is a potent, selective and uncompetitive *acetylcholinesterase* (AChE) inhibitor (IC₅₀=2.95 µM). AChE-IN-25 can be used in Alzheimer's disease research.

HY-N1474

Picfeltarraenin IA	Cholinesterase (ChE)	Cancer Infection Inflammation/Immunology
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation.

HY-N5076

Picfeltarraenin IV	Cholinesterase (ChE)	Cancer Infection Inflammation/Immunology
Picfeltarraenin IV, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IV can be used for the treatment of herpes infections, cancer and inflammation.

HY-N2211

Picfeltarraenin IB	Cholinesterase (ChE)	Cancer Infection Inflammation/Immunology
Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.

HY-N2043

Huperzine B	Cholinesterase (ChE)	Neurological Disease
Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease.

HY-W004287S

Methyl tridecanoate-d25	Amyloid-β Cholinesterase (ChE)
Methyl tridecanoate-d₂₅ is the deuterium labeled Methyl tridecanoate. Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE)[1].

HY-126237

Acetyllovastatin	Fungal	Infection
Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC₅₀ of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines.

HY-N6894

Pseudocoptisine acetate Isocoptisine acetate	Cholinesterase (ChE)	Inflammation/Immunology
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 12.8 μM. Anti-inflammatory and anti-amnestic effects.

HY-B0732S

Itopride-d6 hydrochloride HSR803-d₆ (hydrochloride)	Cholinesterase (ChE) Dopamine Receptor	Neurological Disease
Itopride-d₆ (hydrochloride) is deuterium labeled Itopride (hydrochloride). Itopride hydrochloride (HSR803), a gastroprokinetic Benzamide (HY-Z0283) derivative, is an inhibitor of acetylcholinesterase (AChE) and dopamine D2 receptor[1][2].

HY-N6894A

Pseudocoptisine chloride Isocoptisine chloride	Cholinesterase (ChE)	Inflammation/Immunology
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 12.8 μM. Anti-inflammatory and anti-amnestic effects.

HY-10400

Ladostigil hemitartrate TV-3326 hemitartrate	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of *cholinesterase* and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease.

HY-B1738

Pralidoxime	Cholinesterase (ChE)	Neurological Disease
Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning.

HY-B1200

Pralidoxime chloride 2-PAM chloride	Cholinesterase (ChE)	Neurological Disease
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning.

HY-N4119

Neoeriocitrin	Cholinesterase (ChE)	Neurological Disease
Neoeriocitrin, isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.

HY-101653

MHP 133	Cholinesterase (ChE) mAChR 5-HT Receptor	Neurological Disease
MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with K_i of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.

HY-N7010

(-)-Corynoxidine	Cholinesterase (ChE) Bacterial	Infection
(-)-Corynoxidine is an *acetylcholinesterase* inhibitor with an IC₅₀ value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.

HY-131768

2'-O-Succinyl-cAMP	Cholinesterase (ChE)	Others
2'-O-Succinyl-cAMP is a cAMP analog that can be covalently coupled to acetylcholinesterase. 2'-O-Succinyl-cAMP conjugate has been used as tracers in a classical heterogeneous competitive enzyme immunoassay allowing the determination of cAMP.

HY-B1738A

Pralidoxime iodide	Cholinesterase (ChE)	Neurological Disease
Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning.

HY-A0009

Galanthamine hydrobromide Galantamine hydrobromide	Cholinesterase (ChE) nAChR	Neurological Disease
Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α₃β₄, α₄β₂, α₆β₄ nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD).

HY-B1881

Pirimiphos-methyl	Parasite Cholinesterase (ChE)	Infection
Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains.

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP.

HY-N6608

Physostigmine Eserine	Cholinesterase (ChE)	Neurological Disease
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.

HY-N2230

N-p-trans-Coumaroyltyramine	Cholinesterase (ChE) Parasite	Infection Neurological Disease
N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC₅₀ of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC₅₀ of 13.3 µM for T. brucei rhodesiense.

HY-124957

β-NETA	Cholinesterase (ChE) Apoptosis	Cancer
β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC₅₀=76 μM) and *cholinesterase* (ChE; IC₅₀=40 µM) inhibitor. β-NETA weakly inhibits *acetylcholinesterase* (AChE; IC₅₀=1 mM).

HY-145833A

sEH/AChE-IN-4	Epoxide Hydrolase Cholinesterase (ChE)	Cancer Neurological Disease
sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC₅₀ values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively.

HY-103373

PE154	Cholinesterase (ChE)	Neurological Disease
PE154 (Compound 13) is a potent fluorescent inhibitor of human *acetylcholinesterase* (AChE) and butyrylcholinesterase (BChE) (IC₅₀s=280 pM and 16 nM, respectively). PE154 can label β-amyloid plaques in histochemical analysis.

HY-121467

Acotiamide Z-338 free base; YM443 free base	Cholinesterase (ChE)	Metabolic Disease Inflammation/Immunology
Acotiamide is an orally active, selective and reversible *acetylcholinesterase* (AChE) inhibitor, with an IC₅₀ of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.

HY-121467A

Acotiamide hydrochloride Z-338; YM443	Cholinesterase (ChE)	Metabolic Disease Inflammation/Immunology Others
Acotiamide hydrochloride is an orally active, selective and reversible *acetylcholinesterase* (AChE) inhibitor, with an IC₅₀ of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.

HY-145833

sEH/AChE-IN-3	Epoxide Hydrolase Cholinesterase (ChE)	Cancer Neurological Disease
sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC₅₀ values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively.

HY-145831

sEH/AChE-IN-1	Cholinesterase (ChE)	Inflammation/Immunology Neurological Disease
sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-1 has the potential for the research of Alzheimer's disease (AD).

HY-145832

sEH/AChE-IN-2	Cholinesterase (ChE)	Inflammation/Immunology Neurological Disease
sEH/AChE-IN-2 (Compound 12b) is a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer's disease (AD).

HY-B1266

Physostigmine salicylate Eserine salicylate	Cholinesterase (ChE)	Neurological Disease
Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning.

HY-P0184

Camstatin	NO Synthase	Neurological Disease
Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase.

HY-P0184A

Camstatin TFA	NO Synthase	Neurological Disease
Camstatin TFA, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase.

HY-115910

Y13g	Cholinesterase (ChE) Interleukin Related	Neurological Disease
Y13g is the potent inhibitor of both AChE and IL-6. Interleukin-6 (IL-6) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g reverses the STZ-induced memory deficit, and shows histopathology similarly as in normal animals.

HY-N7263

Galanthamine N-Oxide	Cholinesterase (ChE)	Neurological Disease
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes.

HY-N2320

Physostigmine hemisulfate Eserine hemisulfate	Cholinesterase (ChE)	Neurological Disease
Physostigmine hemisulfate (Eserine hemisulfate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning.

HY-N10781

Isograndifoliol	Cholinesterase (ChE)	Cancer Neurological Disease Cardiovascular Disease
Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC₅₀ value of 0.9 μM. And Isograndifoliol moderately inhibits *acetylcholinesterase* (AChE) with an IC₅₀ value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases.

HY-N6608S

Physostigmine-d3 Eserine-d₃	Cholinesterase (ChE)	Neurological Disease
Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].

HY-B2155

Acotiamide monohydrochloride trihydrate	Cholinesterase (ChE)	Metabolic Disease Inflammation/Immunology
Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible *acetylcholinesterase* (AChE) inhibitor, with IC₅₀ of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .

HY-B0815S

Chlorpyrifos-d10	Cholinesterase (ChE)	Neurological Disease
Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-147658

AChE/BChE/BACE-1-IN-1	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC₅₀ values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential.

HY-10399

Ladostigil TV-3326	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Ladostigil (TV-3326) is an orally active dual inhibitor of *cholinesterase* and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease.

HY-146399

AChE/BChE-IN-9	Cholinesterase (ChE) ROS Kinase	Neurological Disease
AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC₅₀ values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC₅₀ of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β_{1-42. AChE-IN-16 can cross the BBB}.

HY-10399A

Ladostigil hydrochloride TV-3326 hydrochloride	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of *cholinesterase* and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease.

HY-146663

AChE/BChE-IN-3	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-3 (BMC-1) is a dual AChE and BChE inhibitor with IC₅₀ values of 6.08 μM and 0.383 μM against electric eel AChE (elAChE) and equine serum BChE (eqBChE), respectively.

HY-150537

AChE/GSK-3β-IN-1	Cholinesterase (ChE) GSK-3 Microtubule/Tubulin ROS Kinase	Neurological Disease
AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual AChE/GSK-3β inhibitor with IC₅₀ values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB). AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research.

HY-147659

AChE/BChE/BACE-1-IN-2	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC₅₀ values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential.

HY-146312

AChE/BChE/MAO-B-IN-1	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependent AChE, BChE and MAO-B inhibitor with IC₅₀ values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity.

HY-146663A

AChE/BChE-IN-3 hydrochloride	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-3 (BMC-1) hydrochloride is a dual AChE and BChE inhibitor with IC₅₀ values of 6.08 μM and 0.383 μM against electric eel AChE (elAChE) and equine serum BChE (eqBChE), respectively.

HY-N2511S

Trimyristin--d15	Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively[1].

HY-108477

TMPyP4 tosylate TMP 1363	G-quadruplex Telomerase Cholinesterase (ChE) SARS-CoV	Cancer
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an *acetylcholinesterase* inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2.

HY-P3124

BIM-23190	Somatostatin Receptor	Cancer
BIM-23190, a somatostatin analog, a selective SSTR2 and SSTR5 agonist, exhibits K_i values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.

HY-P3124A

BIM-23190 hydrochloride	Somatostatin Receptor	Cancer
BIM-23190 hydrochloride, a somatostatin analog, a selective SSRT2 and SSRT5 agonist, exhibits K_i values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.

HY-17387

(-)-Huperzine A Huperzine A	Cholinesterase (ChE) Apoptosis iGluR	Neurological Disease
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.

HY-N0801

Polygalacic acid	MMP Cholinesterase (ChE)	Inflammation/Immunology Neurological Disease
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.

HY-146665

AChE/BChE-IN-5	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-5 (BMC-16) is a dual AChE and BChE inhibitor with IC₅₀ values of 266 nM and 10.6 nM against human AChE (hAChE) and human BChE (hBChE), respectively. AChE/BChE-IN-5 can cross the BBB.

HY-149012

AChE/hCA I/II-IN-1	Cholinesterase (ChE) Carbonic Anhydrase	Endocrinology Neurological Disease
AChE/hCA I/II-IN-1 (Compound 6) is a potent inhibitor of AChE/Hca with IC₅₀ values of 22.21, 60.79 and 66.64 nM for AChE, Hca Ⅰ and Hca Ⅱ. AChE/hCA I/II-IN-1 can be used for the rsearch for glaucoma, Alzheimer's disease, diabetes.

HY-108048

Desoxypeganine Deoxypeganine; Deoxyvasicine	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC₅₀ values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research.

HY-146664

AChE/BChE-IN-4	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-4 (BMC-3) is a dual AChE and BChE inhibitor with IC₅₀ values of 792 nM and 2.2 nM against human AChE (hAChE) and human BChE (hBChE), respectively. AChE/BChE-IN-4 can cross the BBB.

HY-136610

Chlorpyrifos-oxon	Cholinesterase (ChE)	Neurological Disease
Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function.

HY-N10917

Xanthohumol I	Cholinesterase (ChE)	Cancer Infection
Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067). Xanthohumol is a Cholinesterase (ChE) inhibitor, which inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) wih IC₅₀s of 71.34 μM and 32.67 μM, respectively. The hydroxy compound of Xanthohumol (3-hydroxy-xanthohumol), also shoes inhibitory effect on AChE and BChE with IC₅₀s of 51.25 μM and 63.07 μM.

HY-N2425

Rhodiosin	Cholinesterase (ChE)	Metabolic Disease
Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC₅₀ of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC₅₀ ranged from 57.50 to 2.43 μg/mL. Rhodiosin exhibits potent DPPH free radical scavenging activities, with an IC₅₀ of 27.77 μM.

HY-N0241

Rhodionin	Cholinesterase (ChE)	Metabolic Disease
Rhodionin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC₅₀ of 0.761 μM and a Ki of 0.769 μM. Rhodionin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC₅₀ ranged from 57.50 to 2.43 μg/mL. Rhodionin exhibits potent DPPH free radical scavenging activities, with an IC₅₀ of 19.49 μM.

HY-N2925

β-Amyrone β-Amyron	Fungal COX PPAR	Infection Metabolic Disease Inflammation/Immunology
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity.

HY-138097

α-NETA	Aldehyde Dehydrogenase (ALDH) Cholinesterase (ChE) Apoptosis	Cancer
α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC₅₀ of 9 μM. α-NETA is a potent ALDH1A1 (IC₅₀=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits *cholinesterase* (ChE; IC₅₀=84 µM) and *acetylcholinesterase* (AChE; IC₅₀=300 µM). α-NETA has anti-cancer activity.

HY-146383

H3R antagonist 2	Histamine Receptor Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
H3R antagonist 2 (Compound 23) is a multitarget histamine H₃ receptor (H₃R) antagonist with a K_i of 170 nM for hH₃R . H3R antagonist 2 shows inhibitory effects with IC₅₀ values of 180, 880 and 775 nM for *acetylcholinesterase, butyrylcholinesterase* and human monoamine oxidase B (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB.

HY-N6805

Isoeugenol acetate Acetyl isoeugenol	Cholinesterase (ChE)	Cancer Inflammation/Immunology
Isoeugenol acetate (Acetyl isoeugenol), an essential oil constituent of nutmeg, clove, and cinnamon, shows excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enzymes (IC₅₀=77 nM; K_i=16 nM), α-glycosidase (IC₅₀=19.25 nM; K_i=21 nM), and α-amylase (IC₅₀=411.5 nM). Isoeugenol acetate is used medical and cosmetics industries for its antioxidant, anticancer, antimicrobial and anti-inflammatory properties.

HY-147954

α-Glycosidase-IN-1	Carbonic Anhydrase Cholinesterase (ChE)	Metabolic Disease Neurological Disease
α-Glycosidase-IN-1 (compound MZ7) is a potent α-GLY (α-Glycosidase) inhibitor, with an IC₅₀ of 44.72 nM and a K_I of 41.74 nM. α-Glycosidase-IN-1 also shows inhibition profile against human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), and acetylcholinesterase (AChE), with IC₅₀ values of 104.87, 100.04, and 654.87 nM, respectively. α-Glycosidase-IN-1 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy.

HY-144790

AChE-IN-12	Amyloid-β Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC₅₀s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC₅₀ = 8.8 µM). AChE-IN-12 has remarkable inhibition of self- and Cu²⁺-induced Aβ_1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease.

HY-16697

CID 16020046	GPR55	Cancer
CID 16020046 is a potent and selective GPR55 antagonist and inhibits GPR55 constitutive activity with an IC₅₀ of 0.15 μM. CID 16020046 inhibits GPR55-mediated Ca²⁺ signaling and GPR55-mediated ERK1/2 phosphorylation. CID 16020046 reduces wound healing in endothelial cells and is involved in the regulation of platelet function.

HY-P3143

BMSpep-57	PD-1/PD-L1	Cancer
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs.

HY-P3143A

BMSpep-57 hydrochloride	PD-1/PD-L1	Cancer
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs.

Cat. No.	Product Name	Type

HY-103373

PE154	Fluorescent Dyes/Probes
PE154 (Compound 13) is a potent fluorescent inhibitor of human *acetylcholinesterase* (AChE) and butyrylcholinesterase (BChE) (IC₅₀s=280 pM and 16 nM, respectively). PE154 can label β-amyloid plaques in histochemical analysis.

Cat. No.	Product Name	Type

HY-P2860

Acetylcholinesterase

ACHE; EC 3.1.1.7

Enzyme

Acetylcholinesterase (ACHE; EC 3.1.1.7) is a cholinergic enzyme mainly found in neuromuscular junctions and cholinergic type chemical synapses, and is often used in biochemical research. Acetylcholinesterase catalyzes the breakdown or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetate and choline. Acetylcholinesterase's main role is to terminate neuronal transmission and signaling between synapses to prevent ACh spread and activation of nearby receptors.

HY-P2798

Cholinesterase
EC 3.1.1.8; BCHE
Enzyme

Cholinesterase infers to acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). AChE and BChE catalyze the hydrolysis of 6-MAM to morphine.

Cat. No.	Product Name	Target	Research Area

HY-P2860

*Acetylcholinesterase* ACHE; EC 3.1.1.7	Cholinesterase (ChE)	Neurological Disease
Acetylcholinesterase (ACHE; EC 3.1.1.7) is a cholinergic enzyme mainly found in neuromuscular junctions and cholinergic type chemical synapses, and is often used in biochemical research. Acetylcholinesterase catalyzes the breakdown or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetate and choline. Acetylcholinesterase's main role is to terminate neuronal transmission and signaling between synapses to prevent ACh spread and activation of nearby receptors.

HY-P1016A

BQ-3020 TFA	Endothelin Receptor	Cardiovascular Disease Endocrinology
BQ-3020 (TFA) is a selective agonist of ET_B receptor, inhibits [¹²⁵I]ET-1 binding to ET_B receptor with an IC₅₀ of 0.2 nM in cerebellum, and causes vasoconstriction.

HY-P3714

p-Aminophenylacetyl-tuftsin
Peptides Others

p-Aminophenylacetyl-tuftsin is an active synthetic petide. p-Aminophenylacetyl-tuftsin can be used for the research of various diseases.

HY-P2161B

TAK-683 acetate	Kisspeptin Receptor	Cancer
TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P2161A

TAK-683 TFA	Kisspeptin Receptor	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P2161

TAK-683	Kisspeptin Receptor	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P3061

[Hyp3]-Bradykinin	Bradykinin Receptor	Endocrinology Cardiovascular Disease
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts.

HY-P2798

*Cholinesterase* EC 3.1.1.8; BCHE	Endogenous Metabolite	Others
Cholinesterase infers to acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). AChE and BChE catalyze the hydrolysis of 6-MAM to morphine.

HY-P3910

[Val4] Angiotensin III	Peptides	Cardiovascular Disease
[Val4] Angiotensin III is an angiotension III peptide. [Val4] Angiotensin III is a potent full agonist of Gα_q and βarr2 response, with pEC₅₀ values of 8.31 and 8.44, respectively.

HY-P3532

FGL acetate
Peptides Neurological Disease

FGL acetate is a neural cell adhesion molecule (NCAM) derived motif and can be used for the research of neurogenesis.

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP.

HY-P0184

Camstatin
NO Synthase Neurological Disease

Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase.

HY-P0184A

Camstatin TFA	NO Synthase	Neurological Disease
Camstatin TFA, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase.

HY-P3124

BIM-23190	Somatostatin Receptor	Cancer
BIM-23190, a somatostatin analog, a selective SSTR2 and SSTR5 agonist, exhibits K_i values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.

HY-P3124A

BIM-23190 hydrochloride	Somatostatin Receptor	Cancer
BIM-23190 hydrochloride, a somatostatin analog, a selective SSRT2 and SSRT5 agonist, exhibits K_i values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.

HY-P3469A

Dasiglucagon acetate
Peptides Metabolic Disease

Dasiglucagon acetate is a human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research.

HY-P3143

BMSpep-57	PD-1/PD-L1	Cancer
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs.

HY-P3143A

BMSpep-57 hydrochloride	PD-1/PD-L1	Cancer
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs.

Cat. No.	Product Name	Target	Category

HY-N1089

Vincosamide	Cholinesterase (ChE)	Alkaloids Indole Alkaloids Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Rubiaceae Uncaria rhynchophylla (Miq.) Miq. ex Havil.
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the *acetylcholinesterase* (AChE) activity with anti-inflammatory activity.

HY-N10209

Paecilomide	Cholinesterase (ChE)	Alkaloids Pyridine Alkaloids Classification of Application Fields Disease Research Fields Other Diseases Source classification Microorganisms
Paecilomide is a pyridone alkaloid and *acetylcholinesterase* inhibitor.

HY-75247

Coumaran 2,3-Dihydrobenzofuran	Cholinesterase (ChE) Endogenous Metabolite	Structural Classification Natural Products Verbenaceae Endogenous metabolite Plants Lantana camaraLinn. Source classification
Coumaran (2,3-Dihydrobenzofuran) is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide.

HY-N0528

Linarin Buddleoside; Linarine	Cholinesterase (ChE)	Flavones Structural Classification Flavonoids Labiatae Plants Source classification Eupatorium chinenseL.
Linarin (Buddleoside), isolated from the flower extract of Mentha arvensis, shows selective dose dependent inhibitory effect on acetylcholinesterase (AChE).

HY-N6575

7β-Hydroxybufalin	Glucosidase Cholinesterase (ChE)	Steroids Cardiacglycosides Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Animals
7β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and *acetylcholinesterase*.

HY-124140

Heliosupine	Cholinesterase (ChE)	Alkaloids Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Boraginaceae Heliotropium indicum L.
Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores.

HY-N7480A

Quinolactacin A1	Cholinesterase (ChE)	Alkaloids Quinoline Alkaloids Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Neurological Disease Source classification Microorganisms
Quinolactacin A1 is a potent *acetylcholinesterase* (AChE) inhibitor from solid state fermentation of Penicillium citrinum 90648. Quinolactacin A1 can be used for the research of Alzheimer disease.

HY-N6619A

Lycoramine	Cholinesterase (ChE)	Alkaloids Other Alkaloids Source classification Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.
Lycoramine, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor.

HY-N6619

Lycoramine hydrobromide	Cholinesterase (ChE)	Alkaloids Other Alkaloids Source classification Plants other families
Lycoramine hydrobromide, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine hydrobromide is a potent acetylcholinesterase (AChE) inhibitor.

HY-N6310

Talaromycesone A	Bacterial	Phenols Monophenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Infection Source classification Microorganisms
Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC₅₀ of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC₅₀ of 7.49 μM.

HY-N2511

Trimyristin	Cholinesterase (ChE) Phosphatase Endogenous Metabolite	Natural Products Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Myristicaceae Myristica fragrans Houtt. Endogenous metabolite
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits *acetylcholinesterase* (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively.

HY-122957

Huperzine C	Cholinesterase (ChE)	Alkaloids Other Alkaloids Source classification Plants Lycopodiaceae Lycopodium serratum Thunb．
Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC₅₀ of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease.

HY-N8161

Kaempferol-3,7-di-O-β-glucoside Kaempferol 3,7-diglucoside	Glucosidase Cholinesterase (ChE)	Flavonoids Flavonols Phenols Polyphenols Source classification Plants other families
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, α-glucosidase and *Acetylcholinesterase*. Kaempferol-3,7-di-O-β-glucoside protects differentiating neuronal cells, SH-SY5Y from Amyloid β peptide-induced injury. Kaempferol-3,7-di-O-β-glucoside has the potential for Alzheimer's research.

HY-N5077

Sinapine	Cholinesterase (ChE) P-glycoprotein	Alkaloids Other Alkaloids Monophenols Phenols Inflammation/Immunology Neurological Disease Disease Research Fields Classification of Application Fields Source classification Plants Cruciferae
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

HY-N5077B

Sinapine hydroxide	Cholinesterase (ChE) P-glycoprotein	Alkaloids Other Alkaloids Phenols Monophenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Neurological Disease Source classification Plants other families
Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

HY-N0450

Sinapine thiocyanate	P-glycoprotein Cholinesterase (ChE)	Alkaloids Other Alkaloids Monophenols Phenols Structural Classification Cruciferae Plants Source classification Disease Research Fields Cancer Classification of Application Fields
Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

HY-N0342

Scopoletin Gelseminic acid; Chrysatropic acid	Cholinesterase (ChE) Apoptosis	Coumarins Phenylpropanoids Monophenols Phenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Rubiaceae Hedyotis diffusa Willd.
Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-N10060

Millmerranone A
Cholinesterase (ChE) Terpenoids Other Terpenoids Source classification Microorganisms

Millmerranone A shows the acetylcholinesterase inhibitory property.

HY-76299

Galanthamine Galantamine	Cholinesterase (ChE) Apoptosis	Alkaloids Other Alkaloids Source classification Plants other families
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N0810

Timosaponin AIII	Cholinesterase (ChE)	Steroids Structural Classification Anemarrhena asphodeloides Bunge Liliaceae Plants Source classification Neurological Disease Disease Research Fields Cancer Classification of Application Fields
Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC₅₀ of 35.4 μM.

HY-113626

(-)-Cyclopenin (-)-Cyclopenine	Cholinesterase (ChE)	Alkaloids Other Alkaloids Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Microorganisms
(-)-Cyclopenin ((-)-Cyclopenine) is the enantiomer of Cyclopenin. Cyclopenin is a selective *acetylcholinesterase* (AChE) inhibitor with the IC₅₀ of 2.04 μM.

HY-N4261

Dehydronuciferine	Cholinesterase (ChE)	Alkaloids Quinoline Alkaloids Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants other families
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 25 μg/mL.

HY-N7612

N-Desmethyl Galanthamine N-Norgalanthamine	Cholinesterase (ChE)	Alkaloids Other Alkaloids Other Diseases Disease Research Fields Classification of Application Fields Source classification Plants other families
N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-W004287

Methyl tridecanoate	Amyloid-β Cholinesterase (ChE)	Natural Products Source classification Plants other families
Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).

HY-N2176A

(±)-Marmesin	Cholinesterase (ChE)	Coumarins Structural Classification Phenylpropanoids Source classification Plants Rutaceae Coleonema album (Thunb.) Bartl. & H.L.Wendl.
(±)-Marmesin is a good precursor of the linear furanocoumarins. (±)-Marmesin derivatives have high degree of *acetylcholinesterase* inhibitory property.

HY-N0286

Isoimperatorin	Cholinesterase (ChE) Bacterial	Coumarins Phenylpropanoids Neurological Disease Disease Research Fields Cancer Classification of Application Fields Source classification Plants Umbelliferae Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. e
Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC₅₀ of 74.6 μM.

HY-N5120

Dihydrowithaferin A 2,3-Dihydrowithaferin A	Cholinesterase (ChE)	Steroids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Solanaceae Withania somnifera
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE).

HY-N9513

Echimidine N-oxide	Cholinesterase (ChE)	Alkaloids Pyrrole Alkaloids Source classification Plants Boraginaceae Echium vulgare L.
Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC_{50=0.347 mM).}

HY-131413

O-Desmethyl Galanthamine Sanguinine	Cholinesterase (ChE)	Alkaloids Other Alkaloids Phenols Monophenols Source classification Plants Cornaceae Cornus sanguinea Walter
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 1.83 μM.

HY-N0825

Nodakenin	Cholinesterase (ChE)	Coumarins Phenylpropanoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Umbelliferae Angelica decusiva (Miq.) Franch. et Sav.
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM.

HY-N2192

Swertianolin	Cholinesterase (ChE) HBV Bacterial	Phenols Xanthones Polyphenols Structural Classification Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms. ex C. B. Clark Plants Source classification Gentianaceae Inflammation/Immunology Disease Research Fields Classification of Application Fields
Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin also exhibits anti-HBV and anti-bacterial activity.

HY-N6895

Violanthin	Cholinesterase (ChE)	Phenols Polyphenols Flavones Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Orchidaceae Dendrobium officinale Kimura et Migo other families
Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC₅₀ value of 79.80 μM.

HY-N0826

Corynoline	Cholinesterase (ChE) Keap1-Nrf2	Alkaloids Isoquinoline Alkaloids Classification of Application Fields Disease Research Fields Cancer Neurological Disease Source classification Plants other families
Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM. Corynoline exhibits anti-inflammatory activity by activating Nrf2.

HY-17388

(±)-Huperzine A	Cholinesterase (ChE)	Terpenoids Sesquiterpenes Source classification Plants Huperziaceae Huperzia serrata
(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).

HY-W017423

(-)-Carvone	Cholinesterase (ChE)	Ketones, Aldehydes, Acids Plants Umbelliferae Carum carvi Linn
(-)-Carvone is an insect neurotoxin and a irreversible *acetylcholinesterase* (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae.

HY-N1474

Picfeltarraenin IA	Cholinesterase (ChE)	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Infection Inflammation/Immunology Source classification Plants Scrophulariaceae Picria felterrae Lour.
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation.

HY-N5076

Picfeltarraenin IV	Cholinesterase (ChE)	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Infection Inflammation/Immunology Source classification Plants Leguminosae Sophora flavescens
Picfeltarraenin IV, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IV can be used for the treatment of herpes infections, cancer and inflammation.

HY-N2211

Picfeltarraenin IB	Cholinesterase (ChE)	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Infection Inflammation/Immunology Source classification Plants Scrophulariaceae Scrophularia ningpoensis Hemsl.
Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.

HY-N2043

Huperzine B	Cholinesterase (ChE)	Alkaloids Pyridine Alkaloids Piperidine Alkaloids Source classification Plants Lycopodiaceae Lycopodium serratum Thunb．
Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease.

HY-N6894

Pseudocoptisine acetate Isocoptisine acetate	Cholinesterase (ChE)	Alkaloids Isoquinoline Alkaloids Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Rutaceae Phellodendron amurense Rupr.
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 12.8 μM. Anti-inflammatory and anti-amnestic effects.

HY-N6894A

Pseudocoptisine chloride Isocoptisine chloride	Cholinesterase (ChE)	Alkaloids Isoquinoline Alkaloids Piperidine Alkaloids Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Papaveraceae Corydalis turtschaninovii Bess.
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 12.8 μM. Anti-inflammatory and anti-amnestic effects.

HY-N4119

Neoeriocitrin	Cholinesterase (ChE)	Flavonoids Flavonones Phenols Polyphenols Source classification Plants other families
Neoeriocitrin, isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.

HY-N7010

(-)-Corynoxidine	Cholinesterase (ChE) Bacterial	Isoquinoline Alkaloids Alkaloids Infection Disease Research Fields Classification of Application Fields Source classification Plants Papaveraceae Corydalis speciosa Maxim.
(-)-Corynoxidine is an *acetylcholinesterase* inhibitor with an IC₅₀ value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.

HY-A0009

Galanthamine hydrobromide Galantamine hydrobromide	Cholinesterase (ChE) nAChR	Alkaloids Other Alkaloids Source classification Plants Amaryllidaceae
Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α₃β₄, α₄β₂, α₆β₄ nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD).

HY-N6608

Physostigmine Eserine	Cholinesterase (ChE)	Alkaloids Indole Alkaloids Source classification Plants Leguminosae Lablab purpureus (L.) Sweet
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.

HY-N2230

N-p-trans-Coumaroyltyramine	Cholinesterase (ChE) Parasite	Phenylpropanoids Phenols Polyphenols Simple Phenylpropanols Source classification Plants Liliaceae Ophiopogon japonicus (L. f.) Ker-Gawl.
N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC₅₀ of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC₅₀ of 13.3 µM for T. brucei rhodesiense.

HY-N7263

Galanthamine N-Oxide	Cholinesterase (ChE)	Alkaloids Other Alkaloids Structural Classification other families Plants Source classification
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes.

HY-17387

(-)-Huperzine A Huperzine A	Cholinesterase (ChE) Apoptosis iGluR	Sesquiterpenes Alkaloids Terpenoids Pyridine Alkaloids Neurological Disease Disease Research Fields Anti-aging Classification of Application Fields Source classification Plants Huperziaceae Huperzia serrata
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.

HY-N0801

Polygalacic acid	MMP Cholinesterase (ChE)	Triterpenes Terpenoids Source classification Plants Polygalaceae Polygala tenuifolia Willd.
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.

HY-108048

Desoxypeganine Deoxypeganine; Deoxyvasicine	Cholinesterase (ChE) Monoamine Oxidase	Structural Classification Alkaloids Quinoline Alkaloids Source classification Plants Zygophyllaceae Peganum nigellastrum Bunge
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC₅₀ values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research.

HY-N10917

Xanthohumol I	Cholinesterase (ChE)	Structural Classification Phenols Polyphenols Humulus lupulus L. Plants Source classification Moraceae
Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067). Xanthohumol is a Cholinesterase (ChE) inhibitor, which inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) wih IC₅₀s of 71.34 μM and 32.67 μM, respectively. The hydroxy compound of Xanthohumol (3-hydroxy-xanthohumol), also shoes inhibitory effect on AChE and BChE with IC₅₀s of 51.25 μM and 63.07 μM.

HY-N2425

Rhodiosin	Cholinesterase (ChE)	Flavonols Phenols Polyphenols Flavonoids Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Plants Crassulaceae Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Rhodiola rosea Linn.
Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC₅₀ of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC₅₀ ranged from 57.50 to 2.43 μg/mL. Rhodiosin exhibits potent DPPH free radical scavenging activities, with an IC₅₀ of 27.77 μM.

HY-N0241

Rhodionin	Cholinesterase (ChE)	Flavonols Phenols Polyphenols Flavonoids Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Plants Crassulaceae Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Rhodiola rosea Linn.
Rhodionin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC₅₀ of 0.761 μM and a Ki of 0.769 μM. Rhodionin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC₅₀ ranged from 57.50 to 2.43 μg/mL. Rhodionin exhibits potent DPPH free radical scavenging activities, with an IC₅₀ of 19.49 μM.

HY-N2925

β-Amyrone β-Amyron	Fungal COX PPAR	Triterpenes Structural Classification Sambucus adnata Wall. ex DC. Caprifoliaceae Plants Source classification
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity.

HY-N6805

Isoeugenol acetate Acetyl isoeugenol	Cholinesterase (ChE)	Phenylpropanoids Simple Phenylpropanols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Annonaceae Cananga odorata
Isoeugenol acetate (Acetyl isoeugenol), an essential oil constituent of nutmeg, clove, and cinnamon, shows excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enzymes (IC₅₀=77 nM; K_i=16 nM), α-glycosidase (IC₅₀=19.25 nM; K_i=21 nM), and α-amylase (IC₅₀=411.5 nM). Isoeugenol acetate is used medical and cosmetics industries for its antioxidant, anticancer, antimicrobial and anti-inflammatory properties.

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Product Name	Species	Source

HY-P72811

Acetylcholinesterase/ACHE Protein, Mouse (HEK293, His)
Acetylcholinesterase; AChE
Mouse HEK293

HY-P7847

CutA Protein, Human (His) rHuProtein CutA/CUTA, His; Protein CutA; Acetylcholinesterase-Associated Protein; Brain Acetylcholinesterase Putative Membrane Anchor; CUTA; ACHAP; C6orf82	Human	E. coli

Cat. No.	Product Name

HY-B0882S

Edrophonium-d5 chloride
Edrophonium-d₅ (chloride) is the deuterium labeled Edrophonium chloride. Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.

HY-76299S1

Galanthamine-O-methyl-d3

Galanthamine-O-methyl-d₃ is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
HY-76299S

Galanthamine-d6

Galanthamine-d₆ (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

HY-W004287S

Methyl tridecanoate-d25
Methyl tridecanoate-d₂₅ is the deuterium labeled Methyl tridecanoate. Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE)[1].

HY-B0732S

Itopride-d6 hydrochloride
Itopride-d₆ (hydrochloride) is deuterium labeled Itopride (hydrochloride). Itopride hydrochloride (HSR803), a gastroprokinetic Benzamide (HY-Z0283) derivative, is an inhibitor of acetylcholinesterase (AChE) and dopamine D2 receptor[1][2].

HY-N6608S

Physostigmine-d3

Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].

HY-B0815S

Chlorpyrifos-d10

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-N2511S

Trimyristin--d15
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively[1].

Acetylcholinesterase

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
Products